摘要
目的对白花败酱草的化学成分进行研究。方法通过大孔吸附树脂、Sephadex LH-20、反相HPLC等多种色谱进行分离纯化,根据理化性质和波谱数据进行鉴定。结果从白花败酱草的体积分数70%乙醇提物中分离得到了9个化合物,分别为(E,4R)-4-hydroxy-4,5,5-trimethyl-3-(3-oxobut-1-enyl)cyclohex-2-enone(1),vomifoliol(2),cis-4-hydroxymellein(3),dehydrovomifoliol(4),野鸦椿素A(5),黑麦草内酯(6),对甲氧基苯甲醇(7),sphenanthin A(8)和尿素(9)。结论化合物1~7为首次从败酱属中分离得到。
OBJECTIVE To study the chemical constituents of Whole Plants of Patrinia villosa （ Thunb. ） Juss. METHODS Compounds were isolated by a combination of various chromatographic techniques including column chromatography over macroporous resin, Sephadex LH -20 and reversed-phase HPLC. Their structures were elucidated by physiochemical properties and spectral analy- sis. RESULTS Nine compounds were isolated and identified as （E,4R） -4-hydroxy-4,5,5-trimethyl-3-（3-oxobut-l-enyl） cyclohex-2- enone （ 1 ）, vomifoliol （ 2）, c/s-4-hydroxymellein （ 3 ）, dehydrovomifoliol （4）, 3R, 5S, 6R, 7E, 9S-3,5,6,9-tetrahydroxy-7-megastig- mane （5）, loliolide （6）, 4-methoxybenzyl alcohol （7）, sphenanthin A （8）, and urea （9）. CONCLUSION Compounds 1 - 7 are isolated from Patrinia genus for the first time.
作者
项峥
阎新佳
温静
刘伟
XIANG Zheng YAN Xin-jia WEN Jing LIU Wei(Center of Research on Life Science and Environmental Science College of Pharmacy, Harbin University of Commerce, Harbin 150076, China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2017年第3期185-187,共3页
Chinese Pharmaceutical Journal
基金
国家自然科学基金(青年基金)资助项目(81303211)
中国博士后科学基金(2013M540301)
关键词
白花败酱草
结构鉴定
野鸦椿素A
黑麦草内酯
对甲氧基苯甲醇
Patrinia villosa （ Thunb. ） Juss
structural identification
3R,5S,6R,7E,9S-3,5,6,9-tetrahydroxy-7-megastigmane
lo-liolide
4-methoxybenzyl alcohol
