益气舒心丸对急性冠脉综合征患者预后的影响

Effect of Yiqi Shuxin Pills on prognosis in patients with acute coronary syndrome

目的探讨益气舒心丸(党参、白术、黄芪,等)对急性冠脉综合征(acute coronary syndrome,ACS)患者经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后预后的影响。方法将符合纳入标准的96例ACS患者随机均分为试验组和对照组。PCI术后2组均按照冠心病的二级预防给药,试验组加用益气舒心丸,治疗周期为12个月。比较2组间主要症状积分、次要症状积分、可溶性ST2(soluble ST2,s ST2)水平、中医疗效、心电图疗效的差异和主要心脏不良事件(major adverse cardiovascular events,MACE)发生率的差异。结果试验组中医疗效、心电图疗效均优于对照组,差异具有显著性。治疗6个月和12个月时试验组、对照组主要症状积分、次要症状积分、s ST2较术后24 h内均下降,且试验组下降较对照组更明显,差异具有显著性。试验组心脏不良事件的发生率低于对照组,差异具有显著性。结论益气舒心丸治疗PCI术后的ACS患者疗效显著,改善预后,可作冠心病二级预防的辅助用药。

AIM To investigate the effect of Yiqi Shuxin Pills（ Codonopsis Radix,Atractylodis macrocephalae Rhizoma,Astragali Radix,et al.） on the prognosis in patients with acute coronary syndrome（ ACS） after percutaneous coronary intervention（ PCI） surgery. METHODS Ninety-six satisfactory cases of ACS patients after PCI surgery were at random and equally assigned to control and treatment group. After PCI surgery,both groups received treatment according to the coronary heart disease＇s secondary prevention. The treatment group was treated with Yiqi Shuxin Pills additionally. The treatment duration was 12 months. The differences of major symptoms score,secondary symptoms score,serum s ST2 level,traditional Chinese medicine（ TCM） efficacy,electrocardiogram（ ECG） efficacy as well as the incidence rate of the major adverse cardiovascular events（ MACE） between both groups had been compared. RESULTS The TCM efficacy and ECG efficacy of the treatment group were better than those of the control group with significant difference. After 6 months＇ and 12 months＇ treatment,major symptoms score,secondary symptoms score,serum s ST2 level of the treatment group and the control group were down compared with those in twenty-four hours after PCI surgery,and those of the treatment group decreased more significantly than those of the control group. The differences between them were significant. The incidence rate of the MACE of the treatment group was also lower than that of the control group with significant difference.CONCLUSION Yiqi Shuxin Pills has a significant curative effect on ACS patients after PCI surgery. It could be recommended as an auxiliary medicine for the coronary heart disease＇s secondary prevention.