麻杏乳膏质量标准的研究

Quality standard for Maxing Cream

目的建立麻杏乳膏(炙麻黄、苦杏仁、细辛等)的质量标准。方法 TLC法对黄芪、炙麻黄、防风进行定性鉴别,HPLC定量测定盐酸麻黄碱、盐酸伪麻黄碱、绿原酸含有量。结果 TLC斑点清晰,阴性无干扰。盐酸麻黄碱、盐酸伪麻黄碱、绿原酸分别在0.049 2~0.246 mg/m L(r=0.999 7)、0.026~0.13 mg/m L(r=0.999 3)、0.12~1.20 mg/m L(r=0.999 4)范围内线性关系良好,平均加样回收率分别为96.83%、98.90%、97.30%,RSD分别为1.18%、1.12%、1.86%。结论该方法准确快速,稳定可靠,可用于麻杏乳膏的质量控制。

AIM To establish the quality standard for Maxing Cream（ stir-frying Ephedrae Herba,Armeniacae Semen Amarum,Asari Radix et Rhizoma,etc.）. METHODS TLC was used for the qualitative identification of Astragali Radix,stir-frying Ephedrae Herba and Saposhnikoviae Radix. HPLC was adopted in the quantitative content determination of ephedrine hydrochloride,pseudoephedrine hydrochloride and chlorogenic acid. RESULTS The TLC spots were clear and free from negative interference. Ephedrine hydrochloride,pseudoephedrine hydrochloride and chlorogenic acid showed good linear relationships within the ranges of 0. 049 2- 0. 246 mg / m L（ r =0. 999 7）,0. 026- 0. 13 mg / m L（ r = 0. 999 3） and 0. 12- 1. 20 mg / m L（ r = 0. 999 4）,whose average recoveries were 96. 83%,98. 90% and 97. 30% with the RSDs of 1. 18%, 1. 12% and 1. 86%, respectively.CONCLUSION This accurate,stable and reliable method can be used for the rapid quality control of Maxing Cream.