核糖开关及其在抗菌药物方面的研究进展

Research Progresses on Riboswitches and Their Applications in Antimicrobials

核糖开关是一类与核酸、氨基酸、金属离子、糖类衍生物以及辅酶等特异性配体结合的RNA元件,它与配体结合后通过调控相应下游的基因表达起到控制细胞生命及活动的作用。目前核糖开关是基因调控方面的研究热点,应用于大量筛选工程菌株、构建新型生物传感器以及作为抗菌药作用的新靶点。综述了几种主要的核糖开关(如:嘌呤核糖开关、赖氨酸核糖开关、环二鸟苷酸核糖开关、glm S核糖开关、TPP核糖开关、FMN核糖开关等)在抗菌药物靶点方面的研究进展。

Riboswitch is a class of RNA elements that regulate expressions of corresponding downstream genes and then control cells＇ functions by binding with nucleic acids,amino acids,metal ions,derivatives of carbohydrates and coenzymes. Riboswitch has been a researchfocus in gene regulation in recent years and has been being used in mass screening bacterial strains,constructing new biosensors and as newtarget of antimicrobials. In this paper,recent research progresses on several important classes of riboswitches（such as purine riboswitch,lysine riboswitch,c-di-GMP riboswitch,glm S riboswitch,TPP riboswitch,FMN riboswitch,etc.）in targeting of antimicrobials are mainlyreviewed.