血脂异常与载脂蛋白B代谢缺陷的相关性分析

Study on the correlation between dyslipidemia and defect metabolize of ApoB

目的探讨血生化检验中血液胆固醇异常与载脂蛋白B(ApoB)代谢缺陷的相关性。方法该院健康体检者853例纳入对照者,门诊就诊的血脂异常患者275例纳入研究组。贝克曼5811生化分析仪检测血液中空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)及ApoB的水平,并进行比较,分析ApoB与其他指标的相关性。结果 275例出现血脂异常患者中,原发性血脂水平升高的有49例(17.82%),继发性血脂升高的患者有226例(82.18%)。研究组患者的FPG、TC、TG、LDL-C及ApoB明显高于对照组,差异有统计学意义(P<0.05),血脂异常患者的血清FPG、TC、TG水平与ApoB无显著相关(P>0.05),LDL-C水平与ApoB具有显著的正相关(r=0.455,P=0.001)。结论血脂异常患者FPG、ApoB水平明显升高,FPG、TC、TG、LDL-C与ApoB的代谢异常可能具有一定的关系。

Objective To investigate the relationship between dyslipidemia and defect metabolize of ApoB.Methods A total of 853 healthy people were recruited into the study group in this study,275 patients with dyslipidemia were recruited into the control group.Beckman 5811 biochemical analyzer was used to detect fasting plasma glucose（FPG）,total cholesterol（TC）,three acyl glycerin（TG）,low density lipoprotein（LDL-C）and ApoB,then levels of those indicators were compared in the two groups,and the relationship between ApoB and other indicators were analyzed.Results In 275 patients with dyslipidemia,there were 49cases（17.82%）with primary blood lipid level increasing,and 226cases（82.18%）with secondary blood lipid level increasing.The plasma levels of FPG,TC,TG,LDL-C and ApoB in the study group were significant higher than those in the control group,the differences were statistical significant（P〈0.05）.The correlations between serum levels of FPG,TC,TG and ApoB were not statistical significant（P〈0.05）,the correlation between serum level of LDL-C level and ApoB was statistical significant（P=0.001）.Conclusion Levels of FPG and ApoB in patiens with dyslipidemia significantly elevate,and FPG,TC,TG,LDL-C might had some relationship with metabolic disorder of ApoB.