九江地区2010与2015年入托入学儿童麻疹抗体水平

Comparison of measles antibody levels and trends of children aged 2-10 years between 2010 and 2015 in Jiujiang area,Jiangxi Province

目的了解江西省九江地区2010年与2015年2~10岁入托入学儿童麻疹抗体水平,为探讨阻断麻疹传播策略提供参考。方法于2010年和2015年开展学龄儿童麻疹免疫水平血清流行病学调查,分离血清后采用酶联免疫吸附试验检测抗体。结果 2015年共调查儿童612名,2010年共调查儿童774名,各年龄组麻疹—风疹二联疫苗(MR)、麻疹—腮腺炎—风疹三联疫苗(MMR)接种率均超过95%;城郊儿童麻疹Ig G抗体水平均低于城区,差异均有统计学意义(P值均<0.05)。2015年的城郊、城区、男童、女童和2岁组儿童的GMT均低于2010年,差异均有统计学意义(P值均<0.05)。2015年2岁儿童的抗体阳性率为67.4%(95%CI=58.7%~72.3%),低于2010年的78.5%(95%CI=73.8%~83.9%)(χ~2=45.491,P<0.05)。3~6岁组麻疹抗体阳性率较2岁组上升,但随后抗体阳性率出现下降趋势。结论应进一步加强郊区儿童、2岁组儿童麻疹监测,以及儿童入学入托接种证查验工作,预防麻疹在幼儿园和小学的流行。

Objective To investigate the measles antibody level of children aged 2-10 years old in Jiujiang area of Jiangxi Province, and to explore the strategy of interrupting the spread of measles. Methods The sera-epidemiologieal investigation of measles immune level in children aged 2-10 years old were carried out in 2010 and 2015, and the antibody was detected by enzyme linked immunosorbent assay. Results A total of 612 children in 2015, and a total of 774 cases in 2010 were included, the MR, MMR vaccines coverage were more than 95%; measles IgG antibody levels in suburban children was lower than the city with statistically significant difference（P〈0.05） ; compared to 2010, measles GMT of male, female, and 2 year old age group in children were lower in 2015 with statistically significant difference; the antibody positive rate in children aged 2 years in 2015 was 67.4% （95%CI=58.7%-72.3%）, significantly lower than that in 2010 of 78.5%（95%CI=73.8%-83.9%）; and the antibody positive rate appeared downward trend. Conclusion Measles surveillances in the rural children, two-year-old group of children should be further strengthened, and the children nursery school vaccination certificate inspection work also should be enhanced to prevent measles outbreak in kindergarten.