RhoGDI2在结直肠癌中的表达及临床意义

RhoGDI2 expression and clinical significance in colorectal cancer

目的:探讨RhoGDI2在结直肠癌中表达及临床意义。方法:通过免疫组化检测RhoGDI2在结直肠癌组织、癌旁组织及转移淋巴结中表达,分析其与CRC患者临床因素及生存期之间的关系。结果:RhoGDI2在癌旁组织、肿瘤原发灶及转移淋巴结中表达逐渐升高,差异有统计学意义(P<0.001);RhoGDI2表达与淋巴结转移、远处转移关系密切(P<0.05);高表达RhoGDI2者总生存期及无病生存期短。结论:RhoGDI2在结直肠癌组织中高表达,且与结直肠癌淋巴结转移、远处转移明显相关,高表达RhoGDI2者总生存期及无病生存期短。

Objective： To explore the expression and clinical significance of RhoGDI2 in colorectal cancer. Methods： Immunohistochemistry was used to identify RhoGDI2 expression in clinical samples of colorectal cancer tissues,para-tumorous tissues and lymph node metastasis tissues. The relationships between CRC clinical factors and survival were analyzed. Results： RhoGDI2 expression contributed positively with tumor progression and metastasis in clinical tissues. It was associated with the stage of the tumor,lymph node metastasis,remote metastasis,venous invasion and vessel invasion. Patients with higher RhoGDI2 expression had poorer overall survival. Conclusion： RhoGDI2 showed high expression in colorectal cancer and it was associated with the stage of the tumor,lymph node metastasis,remote metastasis,venous invasion and vessel invasion. Patients with higher RhoGDI2 expression had poorer overall survival.