医用聚乙烯的生物活化和表面仿生矿化研究

The activation and biomimetic mineralization of medical polyethylene

目的本文旨在结合聚乙烯和磷酸钙陶瓷的优良性能,以增强聚乙烯的生物活性。方法采用强酸化学氧化法和"浸蘸-挥干"处理,对聚乙烯表面亲水性进行改善,并通过仿生矿化方法在改性聚乙烯表面制备磷酸钙涂层。结果氧化处理后,聚乙烯表面亲水性明显增强,且经"浸蘸-挥干"和矿化处理后聚乙烯表面快速制备出均匀的磷酸钙涂层。结论该化学表面处理方法简单、快速,能够改善聚乙烯表面的亲水性并在表面快速制备磷酸钙涂层,从而有利于增强聚乙烯的生物活性。

Objective Polyethylene is widely used in craniofacial reconstruction due to its negligible tissue reaction, favorable mechanical properties and biocompatibility. However, its surface hydrophobicity is generally undesirable for cell adhesion and tissue ingrowth. On the other hand, calcium phosphate （CAP） ceramics can form intimate interface with bone tissue but their application in craniofacial reconstruction is limited by their intrinsic brittleness. Therefore, the objective of this study was to combine the desirable surface properties of CaP and the favorable mechanical properties of polyethylene for improving the bioactivity of polyethylene. Methods Polyethylene samples were oxidized with a solution of manganese permanganate in sulfuric acid and to improve their surface hydrophilicity. The oxidized polyethylene sampies were treated by repeated dip-and-dry in a supersaturated calcium phosphate solution and subsequently immersed in the same solution to grow a homogeneous CaP coating. Results The surface hydrophilicity of polyethelye was significantly enhanced after oxidization, and calcium phosphate coating uniformly formed rapidly after dip-and-dry and biomineralized treatment. Conclusion This method is simple and effective to improve the surface hydrophilicity of polyethylene and fabricate calcium phosphate coating rapidly for enhancing polyethylene bioactivity. Meanwhile, the method can be ap plied to other biomedical polymers such as poly-lactide-co-glycolide （PLGA）.