乳腺癌化疗及内分泌治疗相关性脂肪肝的影像学定量评估

Imaging quantification of chemotherapy and endocrine therapy induced fatty liver in breast cancer

脂肪肝是乳腺癌病人化疗及内分泌治疗最常见的肝脏并发症,通常是轻中度的脂肪变性,但严重者可进一步引起肝纤维化、肝硬化、肝癌,甚至肝功能衰竭。脂肪变性是一个可逆的过程,对肝脏脂肪变性的定量动态评估可以早期诊断并干预,为其临床评估及治疗提供参考。目前,多种影像方法可检出及定量评估轻中度脂肪肝,就影像检查在乳腺癌化疗及内分泌治疗相关性脂肪肝的早期诊断及定量评估中的应用进行综述。

Fatty liver is the most common complication in liver during the chemotherapy and endocrine therapy in breast cancer, usually in a level of mild-to moderate. However some severe complications may occur, such as fibrosis, cirrhosis, liver cancer, and liver failure. Since hepatic steatosis is reversible, a dynamically quantitative assessment of hepatic steatosis can contribute to a early diagnosis and intervention, which may provide references for the clinical evaluation and treatment. So far, a variety of noninvasive imaging methods is proposed to identify and assess hepatic steatosis quantitatively, but their sensitivity varies. In this review, we focused on the application of imaging methods in the early diagnosis and quantification of chemotherapy and endocrine therapy induced fatty liver.