摘要
The assessment and management of early-stage atherosclerosis are important for the prevention of cardiovascular disease(CVD).In this study,we used multi-contrast magnetic resonance imaging(MRI) to investigate the carotid plaque feature in asymptomatic,at-risk subjects;we also evaluated the correlation between MRI findings and Framingham risk score(FRS).One hundred sixty-six asymptomatic individuals with risk factors for CVD underwent multi-contrast MRI.After the arterial morphology and plaque components were outlined,the differences in carotid plaque burden among the various risk categories were analyzed.The FRS analysis showed that high-risk individuals had thicker vessel wall and higher plaque lipid content than did low risk participants.A substantial proportion of advanced carotid plaques occurred in low and intermediate-risk groups.Multi-contrast MRI may provide incremental value to the FRS in managing asymptomatic at-risk population.
The assessment and management of early-stage atherosclerosis are important for the prevention of cardiovascular disease （CVD）. In this study, we used multi-contrast magnetic resonance imaging （MRI） to investigate the carotid plaque feature in asymptomatic, at-risk subjects; we also evaluated the correlation between MRI findings and Framingham risk score （FRS）. One hundred sixty-six asymptomatic individuals with risk factors for CVD underwent multi-contrast MRI. After the arterial morphology and plaque components were outlined, the differences in carotid plaque burden among the various risk categories were analyzed. The FRS analysis showed that high-risk individuals had thicker vessel wall and higher plaque lipid content than did low risk participants. A substantial proportion of advanced carotid plaques occurred in low and intermediate-risk groups. Multi-contrast MRI may provide incremental value to the FRS in managing asymptomatic at-risk population.
