质子泵抑制药的药动学研究进展

Study Progress in Pharmacokinetics of Proton Pump Inhibitors

质子泵抑制药(PPIs)为H^+/K^+-ATP酶抑制药,可高效快速抑制胃酸分泌,持续时间长久,是新型抑酸药物。也是目前治疗酸相关疾病如胃食管反流病、消化性溃疡及非甾体类抗炎药引起的相关胃肠病变的首选药物。对基础胃酸、夜间胃酸的分泌,胃泌素和食物刺激后的引起的胃酸分泌均有显著的抑制作用。本文就国内已上市的5种PPIs的药动学特征进行综述。

Proton pump inhibitors are H＋/K＋-ATPase inhibitors, which can efficiently inhibit gastric acid secretion for a long time. As the latest inhibitory gastric acid drugs, proton pump inhibitors are the best choices for acid-related diseases such as gastroe- sophageal reflux disease, peptic ulcer and gastrointestinal lesions caused by nonsteroidal anti-inflammatory drugs. Proton pump inhibi- tors have significant inhibition to basal gastric acid, night gastric acid and gastric acid secretion caused by gastrin and food stimulation. This article reviewed the pharmacokinetic characteristics of five proton pump inhibitors in domestic market.