雾化吸入PGE_1治疗支气管哮喘急性发作对血气分析的影响

Influence on Blood Gas Analysis of Atomization Inhalation of PGE_1 in the Treatment of Bronchial Asthma in Acute Phase

目的:探讨雾化吸入前列腺素E_1(PGE_1)治疗支气管哮喘急性发作期对血气分析水平的影响。方法:选取本院2015年1-12月的50例支气管哮喘急性发作期患者为研究对象,将50例支气管哮喘急性发作期患者随机分为两组,其中对照组24例患者全身应用解痉、平喘、抗感染等常规综合治疗,治疗组26例患者在常规综合治疗的基础上加用雾化吸入PGE1治疗,并比较两组治疗3d后患者的桡动脉血检测PaO_2、PaCO_2指标的变化。结果:治疗组患者经过治疗后总有效率为96.15%,明显高于对照组的67.67%,差异有统计学意义(P<0.05)。治疗后,治疗组的PaO_2、PaCO_2均明显优于对照组,差异均有统计学意义(P<0.05)。结论:加用雾化吸入PGE_1治疗支气管哮喘急性发作期临床效果显著,大大的减少了患者的痛苦,提高了患者的生活质量,值得在临床中推广应用。

Objective：To investigate the effect of inhaled prostaglandin E1（PGE_1） on blood gas analysis in acute exacerbation of bronchial asthma.Method：50 patients with bronchial asthma in acute phase of our hospital from January 2015 to December 2015 were selected as the research objects,the patients were divided into two groups,the control group（24 patients） and treatment group（26 patients）.The control group applied conventional comprehensive treatment such as systemic spasmolysis,relieving asthma,anti-inflammatory,in treatment group who were given routine treatment combined with atomization inhalation of PGE_1.Then compared the patient＇s radial artery blood PaO_2,PaCO_2 index changes between the two groups after treatment 3 days.Result：After treatment,the total effective rate of the treatment group was 96.15%,which was significantly higher than 67.67% of the control group,the difference was statistically significant（P〈0.05）.After treatment,the PaO_2 and PaCO_2 in the treatment group were significantly better than the control group,the differences were statistically significant（P〈0.05）.Conclusion：The clinical effect of inhalation of PGE_1 in the treatment of acute exacerbation of bronchial asthma is significant, greatly reducing the pain of patients,improve the quality of life of patients,it is worthy of clinical application.