NT-proBNP、H-FABP与cTnI联合检测在老年心力衰竭患者中的临床意义

The Significance of Determination of NT-pro BNP,H-FABP and c Tn I in Elderly Patients with Chronic Heart Failure

目的:探讨氨基末端B型钠尿肽原(NT-pro BNP)、心型脂肪酸结合蛋白(H-FABP)、心肌肌钙蛋白I(c Tn I)联合检测在老年心力衰竭(CHF)患者中的临床意义。方法:162例老年CHF患者根据NYHA心功能分级方法分为Ⅰ、Ⅱ、Ⅲ、Ⅳ级,同时选取健康人员50例为对照组,分别检测五组NT-pro BNP、H-FABP、c Tn I水平,并进行对比分析。结果:对照组与心功能Ⅰ级组c Tn I水平比较差异无统计学意义(P>0.05),心功能Ⅱ、Ⅲ、Ⅳ级组c Tn I水平不断升高,组间比较差异有统计学意义(P<0.05)。对照组与各CHF组NT-pro BNP、H-FABP水平比较差异有统计学意义(P<0.05),随着心功能分级增加NT-pro BNP、H-FABP不断升高,组间比较差异有统计学意义(P<0.05)。结论:NT-pro BNP、H-FABP与c Tn I可为疾病的分级提供依据,可作为CHF疗效监测、预后判断及死亡风险评估的客观指标。

Objective：To discuss the clinical significance of determination of NT-pro BNP,H-FABP and c Tn I in elderly patients with chronic heart failure（CHF）.Method：162 elderly patients with CHF were divided into grade Ⅰ,grade Ⅱ,grade Ⅲ,grade Ⅳ according to the NYHA cardiac function classification method,and 50 healthy people were considered as the control group,then NT-pro BNP, H-FABP and c Tn I were detected and contrasted in the people of the five groups.Result：There was no significantly difference in c Tn I between the control group and grade Ⅰgroup（P〉0.05）,but sustainedly increased in grade Ⅱ,grade Ⅲ,and grade Ⅳgroup（P〈0.05）,and all significantly higher than the control group（P〈0.05）.There was significant differerce between control group and heart function classification groups on level of NT-pro BNP and H-FABP（P〈0.05）,and level of NT-pro BNP and H-FABP sustainedly increased with heart function classification increasing（P〈0.05）.Conclusion：NT-pro BNP,H-FABP and c Tn I can provide basis for disease classification,all of which are objective indexes for efficacy monitoring,prognosis judging and mortality risk evaluating in elderly patients with CHF.