恶性积液局部灌药疗效观察

The Clinical Observation of Local Infusion Medicine for Malignant Effusion

目的:总结恶性积液局部灌药的疗效及不良反应。方法:回顾分析2012年2月-2016年3月在笔者所在科治疗的65例恶性积液患者局部灌注药物剂型及用量,评价其疗效及不良反应。结果:局部灌注肿瘤坏死因子(TNF)单药的疗效可达88.2%,而香菇多糖单药的有效率仅66.7%,若香菇多糖联合白介素-2(IL-2)有效率可上升至80.0%,基因治疗药物重组人P53腺病毒注射液的疗效可达77.8%;各组仅有少数出现发热、胸腹痛等不良反应,均为轻至中度,对症治疗可好转。结论:肿瘤晚期合并恶性积液者,局部灌药治疗有效率高,不良反应可控,可明显改善患者的生活质量。

Objective：To explore the curative effect and adverse reaction of local infusion medicine for malignant effusion.Method：The type and dose of local infusion drugs for 65 patients with malignant effusion during February 2012 to March 2016 in our department were analyzed retrospectively,then the curative effect and adverse reactions were evaluated.Result：The curative effect of local infusion Tumor Necrosis Factor（TNF） could achieve to 88.2%,and the efficient of Lentinan single-agent was only 66.7%,the curative effect of Lentinan combined Interleukin-2（IL-2） could be up to 80.0%,the curative effect of gene therapy drug-Recombinant Human P53 Adenovirus injection could be reached to 77.8%.There were only a few adverse reactions such as fever,chest/abdominal pain in each group,the degree was mild to moderate,symptomatic treatment could be improved.Conclusion：For tumor patients with malignant effusion,local infusion medicine treatment has high efficient and controllable adverse reactions,can obviously improve the patient’s quality of life.