慢性乙型肝炎和肝硬化患者血清甲状腺激素水平的分析

Analysis on Serum Thyroid Hormone Levels of Patients with Chronic Hepatitis B and Cirrhosis

目的:探讨慢性乙型肝炎和肝硬化患者血清中三碘甲腺原氨酸(T_3)、甲状腺素(T_4)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)水平的变化情况及其临床意义。方法:收集2014年11月-2015年11月在笔者所在医院住院的轻度慢性乙型肝炎患者100例、中重度乙型肝炎患者54例、肝硬化患者43例,同时选取同一时间内来医院体检的健康者40例为对照(健康组),检测血清中的T_3、T_4、FT_3、FT_4、TSH水平,并对检测结果进行统计分析。结果:T_3、T_4、FT_3、FT_4水平,轻度慢性乙型肝炎组与健康组比较,差异无统计学意义(P>0.05);中重度乙型肝炎组低于健康组,差异有统计学意义(P<0.05);肝硬化组显著低于健康组,差异有统计学意义(P<0.01)。TSH检测结果各组间比较,差异无统计学意义(P>0.05)。结论:肝硬化和中重度乙型肝炎患者血清中的T_3、T_4、FT_3、FT_4相比轻度慢性乙型肝炎患者及健康者都有所降低。

Objective：To investigate the changes and clinical significance of triiodothyronine（T3）,thyroxine（T4）,free triiodothyronine（FT3）,free thyroxine（FT4）,thyroid stimulating hormone（TSH） levels in serum of patients with chronic hepatitis B and patients with cirrhosis.Method：100 cases of patients with mild chronic hepatitis B,54 cases with moderate severe hepatitis B,43 patients with liver cirrhosis were collected from November 2014 to November 2015 in hospital,and also 40 cases of health examination people at that time were selected to make comparison.Serum T3,T4,FT3,FT4,TSH levels were detected,and statistical analysis on test results were made.Result：For average value of T3,T4,FT3,FT4,there was no statistical significance between mild chronic hepatitis B group and healthy group（P〉0.05）.Those in moderate severe hepatitis B group were lower than the healthy group with statistical significance（P〈0.05）.Those in liver cirrhosis group was lower than the healthy group with obvious statistical significance（P〈0.01）.There was no significant difference among all test groups in TSH results（P〉0.05）.Conclusion：The levels of T3,T4,FT3,FT4 in patients with moderate severe hepatitis B and live cirrhosis were lower than those in mild hepatitis patients and the healthy.