同时性结直肠癌肝转移危险因素分析

Simultaneously liver metastasis of colorectal cancer in risk factors analysis

目的:探讨影响结直肠癌肝转移的临床病理相关因素。方法:收集2010年至2014年南京大学鼓楼医院普外科结直肠癌患者201例的临床病理资料,分析同时性结直肠癌肝转移与临床病理因素的关系。采用非条件Logistic回归单因素分析,对有统计学意义的变量进行非条件Logistic回归多因素分析。结果:201例结直肠癌患者中,肝转移45例。单因素分析显示,肿瘤最大径、CEA、CA199、CA125、肿瘤T分期、分化程度、病理组织类型、糖尿病、肿瘤位置、吸烟是影响结直肠癌肝转移的危险因素。Logistic多因素分析,结果显示肿瘤最大径、CEA、CA199、CA125、肿瘤分化程度、病理类型、糖尿病是肝转移的独立危险因素。结论:肿瘤最大径、CEA、CA199、CA125、肿瘤分化程度、病理类型、糖尿病是同时性结直肠癌肝转移的独立危险因素。

Objective： To investigate the clinical and pathological factors associated with colorectal cancer liver metastasis. Methods： Collected clinical data from 2010 to 2014 in Drum Tower Hospital of Nanjing University of general surgery patients with colorectal cancer 201 cases,analyze the relationship between liver metastases of colorectal cancer and clinical pathological factors. Results： Of 201 patients with colorectal cancer,liver metastasis developed in45 cases. Univariate analysis showed that tumor size,CEA,CA199,CA125,tumor T stage,tumor differentiation,pathological type,diabetes,tumor location,smoking were risk factors of liver metastases of colorectal cancer. Logistic multivariate analysis showed that CEA,CA199,CA125,tumor differentiation,pathological type,diabetes were independent risk factors for liver metastasis. Conclusion： CEA,CA199,CA125,tumor differentiation,pathological type,diabetes are independent risk factors for liver metastasis.