Survivin与TSLP在子宫腺肌病中的表达及意义

Expression and significance of Survivin and TSLP in the adenomyosis

目的:检测抑凋亡蛋白Survivin与胸腺基质促淋巴细胞生成素(TSLP)在子宫腺肌病中的表达,探讨Survivin与TSLP在子宫腺肌病发生发展中的关系。方法:采用免疫组化法检测子宫腺肌病中Survivin和TSLP的表达情况,分析两者与子宫腺肌病的关系。结果:Survivin在增生期和分泌期子宫腺肌病的表达,均高于正常子宫内膜,差异具有统计学意义(增生期t=20.239,P<0.01;分泌期t=17.852,P<0.01)。TSLP在增生期和分泌期子宫腺肌病的表达,均高于正常子宫内膜,差异具有统计学意义(增生期t=17.983,P<0.01;分泌期t=13.975,P<0.01)。在子宫腺肌病增生期和分泌期中Survivin与TSLP的表达呈现正相关(增生期r=0.732;分泌期r=0.716)。结论:子宫腺肌病患者的内膜组织中存在Survivin和TSLP的异常高表达,两者在子宫腺肌病的发生及发展过程中有着一定的联系。

Objective： To detect the expression of Survivin and TSLP in adenomyosis. To investigate the relationship between Survivin and TSLP in the development of adenomyosis. Methods： The expression of TSLP and Survivin in the patients with adenomyosis were detected by immunohistochemical method and analyze the relationship of them with the uterine gland. Results： The expression of Survivin in proliferative phase and secretory phase was significantly higher than that in normal endometrium,the difference was statistically significant（ proliferative phase t = 20. 239,P〈0. 01,secretory phase t = 17. 852,P〈0. 01）. The expression of TSLP in proliferative phase and secretory phase was significantly higher than that in normal endometrium,the difference was statistically significant（ proliferative phase t= 17. 983,P〈0. 01,secretory phase t = 13. 975,P〈0. 01）. The expression of and Survivin was positively correlated with the expression of TSLP in the proliferative phase and the secretory phase（ proliferative phase r = 0. 732,secretory phase r = 0. 716）. Conclusion： High expression of Survivin and TSLP in adenomyosis was found. There is a certain relationship between the two in the occurrence and development of adenomyosis.