顶端Na^+依赖性胆汁酸转运体相关研究进展

Advances in studies of ileal apical sodium-dependent bile acid transporter

胆汁酸是体内维持脂质代谢稳态的关键物质,而位于回肠末端黏膜上皮细胞刷状缘侧的顶端Na^+依赖性胆汁酸转运体(ASBT)是在肝肠循环中负责胆汁肠道重吸收的关键转运体,对于维持机体代谢平衡具有重要意义。近年来,随着关于ASBT调控相关机制研究的不断深入以及其在肠道炎症、肠道肿瘤、糖尿病、高脂血症等疾病治疗中发挥的重要作用被不断挖掘,使其有望成为上述疾病治疗的新靶点。本文将综述ASBT表达调控及其在疾病治疗方面的相关研究进展。

Bile acids play critical roles in the regulation of metabolism and absorption of lipids. The ileal apical sodium-dependent bile acid transporter（ASBT） located at the enterocyte brush border is responsible for the reuptake of bile acids and the maintenance of bile acid homeostasis. Recently,a number of investigations have been made concerning the regulation and control of ASBT and the relationship between ASBT and intestinal inflammation,tumorigenesis,diabetes mellitus and hyperlipemia,which suggests ASBT as a potential therapeutic target of these diseases. In this review,advances in the study of above-mentioned issues were summarized.