拟除虫菊酯类农药的免疫毒性研究进展

Research progress on the immunotoxicity of pyrethroids

拟除虫菊酯类杀虫剂因其高效、对哺乳动物低毒和易降解等特性已被广泛使用,目前对其生态毒理学的研究主要集中在神经及内分泌干扰、发育和生殖毒性方面,而关于其免疫毒性的研究也越来越受到了关注。文章对拟除虫菊酯类农药的免疫毒性及其分子机制研究进展进行了总结,主要从免疫器官、免疫细胞、免疫分子和免疫功能等方面综述了此类杀虫剂对不同生物的免疫毒性及其可能的分子机制,同时总结了拟除虫菊酯类杀虫剂暴露与免疫相关疾病发生的关联,以期为拟除虫菊酯类农药免疫毒性的进一步探究提供参考。

Pyrethroids are widely used as they are highly efficient, with low toxicity to mammals and easily degraded. Although the research on toxicity of pyrethroids is mainly focused on neurotoxicity,endocrine disruption, development toxicity and reproductive toxicity, immmunotoxicity of pyrethroids has attracted more and more attention recently. Thus, the research progresses related to the immunotoxcity of pyrethroids are summarized in this review, which include the following three topics,1） the immunotoxicity of pyrethroids to various organisms from the aspects of immune organs, immune cells, immune molecules and immune function; 2） possible molecular mechanism underlying the immunotoxicity of pyrethroids, and 3） the relationship between pyrethroids exposure and occurrence of immune-related diseases. This review will be beneficial for the further research on the elucidation of the immunotoxicity of pyrethroids.