RAS对各肝病影响的研究进展

Research Progress on the Effect of RAS on Liver Diseases

肾素-血管紧张素系统(rennin angiotensin system,RAS)是机体内重要的具有调节血压、水钠平衡等功能的内分泌调节系统。近年在各肝病的研究中发现,RAS失衡与各种肝病的发生与发展均有密切关系。肝组织内存在局部的完整RAS系统,当肝细胞或肝组织受到某种致病因素的刺激时,局部RAS被激活,各成分活性增强并重新分布,继而影响肝病的发展。早期研究已证实ACE-AngⅡ-AT1R轴表达上调可加重肝脏损伤,促进各肝病的进展。新近研究发现的ACE2-Ang(1-7)-Mas轴被不断证明是ACE-AngⅡ-AT1R轴的反向调节轴,被称为"替代RAS经典轴",发挥拮抗ACE-AngⅡ-AT1R轴的作用,对肝病的进展起一定的缓解或逆转作用。本研究就近年来关于RAS对各肝病的影响的相关研究做一综述,为找到更有效的缓解和治愈肝病的新方法提供新思路。

Renin angiotensin system （RAS） is an important endocrine regulation system which has the function of regulating blood pressure, sodium balance and so on. In recent years, it has been found that the imbalance of RAS was closely related to the occurrence and development of various liver diseases. Partial complete RAS system exists in liver tissue, which would be activated when the liver cells or liver tissue were stimulated by some pathogenic factors, and the activity of each component was enhanced and redistributed, which would affect the development of liver diseases. Early studies have confirmed that the up-regulated expression of ACE-AngⅡ -AT1R axis may aggravate liver injury and accelerate the development of various liver diseases. The newly discovered ACE2-Ang （1-7）-Mas axis has been consistently proved to be the reverse regulating shaft of ACEce-Ang Ⅱ -AT1R axis, which is named as ＂Altemative classic axis on RAS＂ and plays the role of antagonizing the ACE-AngⅡ -AT1R axis and alleviating or reversing the progress of liver diseases. This research reviewed the recent studies about the effect of RAS on the development of various liver diseases in order to provide a new way to find a more effective method to relieve and cure liver diseases.