经超声测量的心外膜脂肪厚度与非勺型高血压的相关性研究

The relationship between echocardiographic epicardial adipose tissue thickness and non dipper hypertension

目的研究心外膜脂肪厚度与非勺型原发性高血压的相关性。方法共选取150例研究对象纳入研究，其中勺型高血压组、非勺型高血压组、健康对照组各50例。对所有研究对象进行病史采集及常规化验检查，B超测量心外膜脂肪厚度，24h动态血压监测，对各组之间的心外膜脂肪厚度进行比较，分析心外膜脂肪厚度与非勺型原发性高血压的相关性，通过ROC曲线及最大约登指数得出心外膜脂肪厚度对非勺型原发性高血压的最佳筛查阳性界值。结果与勺型高血压组比较，非勺型高血压组心外膜脂肪厚度明显升高[（6．30±0．94）mmVS（5．92d-0．75）mm，P〈0．05]，与健康组比较，勺型高血压组心外膜脂肪厚度明显升高[（5．92±0．75）mmVS（5．50±0．13）mm，P〈0．05]，心外膜脂肪厚度与非勺型原发性高血压线性相关（r=0．43，P〈0．05），心外膜脂肪厚度诊断非勺型原发性高血压的最佳筛查阳性界值为6．01mm。结论心外膜脂肪厚度与非勺型原发性高血压的存在密切关联。

Objective To investigate the correlation between epicardial fat thickness and non dipper hypertension. Methods A total of 150 subjects was included in the study, of which 50 were in the non dipper hypertension group, the same in the non dipper hypertension group and the healthy control group. History collection and routine laboratory tests, ultrasonic measurement of epicardial fat thickness, and 24 hour ambulatory blood pressure monitoring were carried on all subjects. Epicardial fat thickness between groups was compared to primarily analyze the correlation of epicardial fat thickness and non dipper type hy- pertension. The optimal screening positive value in epicardial fat thickness of non dipper type primary hy- pertension was obtained by receiver operating characteristic （ROC） curve and maximum Youden index. Re- sults When non dipper hypertension group and non - dipper hypertension group were compared, epicardial fat thickness was significantly increased [ （ 6. 30 ~ 0. 94 ） mm vs （ 5.92 ~ O. 75 ） mm, P 〈 0. 05 ], as com- pared dipper hypertension group to healthy group, the epicardial fat thickness was significantly increased [ （ 5.92 ＋ O. 75 ） mm vs （ 5.50 ＋ 0. 13 ） mm, P 〈 0. 05 ]. Epicardial fat thickness and non dipper type prima- ry hypertension were linearly related （r =0. 43 ,P 〈0. 05） , and epicardial fat thickness in diagnosis of non dippers primary hypertension optimal screening positive value was 6. O1 mm. Conclusions There is a close relationship of epicardial fat thickness and non dipper hypertension.