卵巢癌减瘤术结局及病理分期与术前血细胞计数的关系

Correlation between cytoreduction outcome and staging of ovarian cancer with preoperative blood cell count

目的探讨卵巢癌手术减瘤结局及病理分期与血细胞计数的关系。方法回顾性分析2007年1月至2012年6月手术的148例初治卵巢癌患者的手术病理资料及术前全血细胞计数结果，并与同期的96例卵巢良性肿瘤患者资料进行比较。结果卵巢癌组较对照组，晚期组较早期组在白细胞总数、中性粒细胞、淋巴细胞、单核细胞、血小板、中性粒细胞／淋巴细胞（NRL）、血小板／淋巴细胞比值（PRL）上的差异均有统计学意义（P〈0．05），卵巢癌减瘤术理想组较非理想组在血小板、单核细胞、NRL、PRL上的差异有统计学意义（P〈0．05）。结论卵巢癌减瘤术结局及病理分期与术前血细胞计数密切相关，血细胞计数对于卵巢肿瘤良恶性的鉴别、手术减瘤结局及病理分期的预测有重要价值，且可能对病情监测、预后分析有一定意义。

Objective To investigate the relationship between cytoreduction outcome and staging of ovarian cancer with preoperative blood cell count. Methods The data of 148 ovarian cancer patients from January 2007 to June 2012 were analyzed retrospectively. Clinieopathological and blood cell count data were collected, and benign ovarian tumor group （ n = 96） as controls. Results Compared to the control group, there were significant differences in the number of white blood cells, neutrophils, lymphocytes, monocytes, platelets, nentrophil to lymphocyte ratio, and platelets to lymphocyte ratio in patients with ovarian cancer （P 〈 0. 05）. The same results were also observed in advanced groups and early groups. While between op- timal cytoreduction and suboptimal cytoreduction, there were significant differences in platelets, monocytes, neutrophil to lymphocyte ratio, and platelets to lymphocyte ratio （P 〈 0. 05）. Conclusions The cytoreduc- tion outcome and pathological staging of ovarian cancer are closely related to the preoperative blood cell count. Blood cell count is important for the identification of benign and malignant ovarian tumors, cytoreduction outcome and the prediction of pathological staging, and may be of significance to the monitoring and prognosis of the disease.