舒拉明在急性闭角型青光眼滤过性手术后应用的辅助效果

The auxiliary effect of suramin application in acute angle closure glaucoma surgery patients

目的探讨舒拉明在急性闭角型青光眼滤过性手术后应用的辅助效果。方法采用前瞻性研究方法，2012年2月至2016年1月选择急性闭角型青光眼患者178例，根据入院顺序分为观察组与对照组各89例，两组都给予滤过性手术治疗，观察组在术后给予舒拉明辅助治疗，持续时间为术后1-14d，手术后14d观察两组预后情况。结果所有患者都顺利完成手术，术中与术后无严重并发症发生；观察组与对照组术后眼压分别为（11．52±3．24）mmHg和（16．98±5．33）mmHg，与术前[分别为（31．98±5．22）mmHg、（31．87±5．11）mmHg]比较差异有统计学意义（P〈0．05），同时观察组术后眼压也低于对照组（P〈0．05）。观察组与对照组术后的视网膜中央动脉的收缩期峰值流速（PSV）与舒张末期流速（EDV）值均明显高于术前（P〈0．05），观察组术后的PSV与EDV值也明显高于对照组（P〈0．05）。观察组与对照组术后的功能性滤过泡比率分别为80．9％和60．7％，观察组明显高于对照组（P〈0．05）。结论舒拉明在急性闭角型青光眼滤过性手术后应用能促进功能性滤过泡的形成和眼压的降低，提高眼部血流速度，有很好的应用效果。

Objective To investigate the effects of suramin application in acute angle closure glau- coma surgery patients. Methods A prospective study method was used. From February 2012 to January 2016, 178 acute angle closure glaucoma surgeries in our hospital for treatment were selected, and were e- qually divided into observation and control groups （89 cases in each group） according to the order of admission, and two groups were given filtration surgery. The observation group was treated with suramin adjuvant therapy after surgery. The duration were 1 - 14 d after operation. The prognosis of two groups was observed. Results All patients were successfully completed surgery. The intraoperative and postoperative complica- tions were no seriously occurred; the postoperative intraocular pressure in the observation group and the con- trol group were （11.52 ± 3.24） mmHg and （16. 98 ± 5.33 ） mmHg that compared preoperative [ （31.98 ± 5.22） mmHg, （31.87 ± 5.11 ） mmHg ] with significantly different （ P 〈 0. 05 ）, while the observation group was significantly lower than that of the control group （ P 〈 0.05 ）. The postoperative peak systolic ve- locity （PSV） and end diastolic velocity （EDV） values of the central retinal artery of the observation group and the control group were significantly higher than that of preoperation （ P 〈 0. 05 ）, and the postoperative PSV and EDV values of the central retinal artery of the observation group were significantly higher than that in the control group （ P 〈 0. 05 ）. The postoperative ratios of functional filtering bleb in the observation group and control group were 80. 9% and 60. 7% , respectively. The observation group was significantly higher than that of the control group （ P 〈 0. 05）. Conclusions The application of suramin in acute close angle glaucoma filtration surgery can promote the function of fihering bleb and intraocular pressure reduc tion, and improve the ocular blood flow speed that has good application effects.