SOD联合NLR、PCT在肺结核与社区获得性肺炎鉴别诊断中的应用

Significance of detecting SOD,PCT and NLR levels in the differential diagnosis of pulmonary tuberculosis and community-acquired pneumonia

目的:探讨血超氧化物歧化酶(SOD)联合中性粒细胞/淋巴细胞百分比(NLR)、降钙素原(PCT)在肺结核(PTB)与社区获得性肺炎(CAP)中的鉴别诊断价值方法:分别采用全自动生化仪、血细胞分析仪、免疫吸附双抗体夹心检测132例PTB患者、103例社区获得性肺炎(CAP)患者血SOD、白细胞(WBC)、中性粒细胞(N)、淋巴细胞(L)、PCT水平,比较两组指标水平差异并观察SOD与PCT、NLR联合检测对PTB与CAP鉴别诊断价值及对PTB诊断的灵敏度和特异度。结果:PTB患者血SOD、NLR、PCT明显低于CAP患者,差异有统计学意义(P<0.05);PTB组淋巴细胞与CAP组无明显差异(P>0.05)。SOD、NLR、PCT联合检测诊断PTB其ROC曲线下面积>0.9。结论:SOD联合NLR、PCT对PTB及CAP鉴别诊断具有参考价值。

Objective： To assess the clinical value of combined detecting superoxide dismutase（ SOD） levels with neutrophil-to-lymphocyte ratio（ NLR） and procalciptonin（ PCT） in differential diagnosis of pulmonary tuberculosis（ PTB） and community-acquired pneumonia（ CAP）.Methods： Automatic biochemistry analyzer,blood cell analyzer and sandwich ELISA were used to respectively detect SOD,blood leukocytes,neutrophils,lymphocytes and PCT levels in132 patients of PTB and 103 of CAP.The difference were compared,and the sensitivity and specificity of SOD with PCT,NLR in the diagnosis of PTB were assayed between groups.Results： Patients of PTB had lower SOD,PCT and NLR levels than those of CAP（ P〈0. 05）,yet the lymphocyte count remained no significant difference（ P〉0. 05）.The area under the ROC curve was greater than 0. 90 by combined SOD with NLR and PCT detection. Conclusion：SOD combined with PCT and NLR may have reference value for the differential diagnosis of PTB and CAP.