不同光照条件下下丘脑神经肽表达量对中缅树鼩体重调节的影响

Effetcs of hypothalamic neuropeptides expression on body mass regulation under different photoperiods in Tupaia belangeri

为了研究光照对下丘脑神经肽中神经肽Y(Neuropeptide Y,NPY)、刺鼠相关蛋白(Agouti Aelated Peptide,AgRP)、阿片促黑色素原(Pro-opiomelanocortin,POMC)和可卡因-安他非明转录调节肽(Cocaine and Amphetamine Regulated Transcript peptide,CART)表达量在中缅树鼩体重调节中的作用,对中缅树鼩的体重、体脂、食物摄入量、瘦素含量和下丘脑神经肽表达量进行测定。结果表明:短光增加中缅树鼩的体重和体脂,增加食物摄入量。光照不影响中缅树鼩瘦素含量,但瘦素含量与脂肪含量呈正相关关系。下丘脑神经肽基因NPY差异显著,而AgRP、POMC和CART表达量差异不显著。以上结果表明短光可以增加中缅树鼩的体重和体脂,增加摄入量。瘦素通过调节NPY表达量来调节中缅树鼩的体重调节。

In order to investigate the role of Neuropeptide Y（ NPY）,Agouti Aelated Peptide（ AgRP）,Pro-opiomelanocortin（ POMC）,Cocaine and Amphetamine Regulated Transcript（ CART） peptide expression in hypothalamic neuropeptide in body mass regulation in Tupaia belangeri under different photoperiods,body mass,body fat mass,food intake,serum leptin levels and hypothalamic neuropeptide expression were measured. It showed that short photoperiod increased body mass and body fat mass,and increased food intake. But serum leptin levels showed no significant differences between two groups,and leptin levels showed a positive correlation with body fat mass. Hypothalamic neuropeptide NPY had significant difference,but AgRP,POMC and CART expression had not significant differences between two groups. All of the results suggested that short photoperiod can increase the body mass,body fat mass and food intake. Leptin may play an regulation on body mass regulation by acting on hypothalamic neuropeptide of NPY expression in T. belangeri.