Lipiview~眼表面干涉仪辅助的中老年人干眼症状与体征的相关性研究

Study on correlation of dry eye symptoms and signs in middle-aged and aged people by Lipiview^(?)ocular surface interferometry

目的应用Lipiview~眼表面干涉仪辅助分析中老年人干眼症状与体征的相关性。方法选取85例(170眼)55~80岁中老年人为研究对象,进行快速干眼评估问卷(standard patient evaluaion of eye dryness,SPEED)调查,Lipiview~眼表面干涉仪进行泪膜脂质层厚度及其波动性测量和不完全眨眼比例检查。采用Spearman秩相关性分析干眼症状与泪膜脂质层厚度、泪膜脂质层厚度的波动性及不完全眨眼比例之间的关系。结果SPEED评分为(6.13±4.60)分,泪膜脂质层厚度为(74.88±21.16)nm,泪膜脂质层厚度的波动性为4.47±3.40,不完全眨眼比例为0.62±0.36。SPEED评分与泪膜脂质层厚度呈负相关(r=-0.823,P=0.000),与泪膜脂质层厚度的波动性呈负相关(r=-0.268,P=0.018)。泪膜脂质层厚度的波动性与泪膜脂质层厚度呈正相关(r=0.339,P=0.030),与不完全眨眼比例呈负相关(r=-0.303,P=0.008)。SPEED评分与不完全眨眼比例无明显相关性(P>0.05)。结论中老年干眼的症状与泪膜脂质层厚度及泪膜脂质层厚度的波动性三者之间存在着相关性。不完全眨眼比例与泪膜脂质层厚度的波动性之间存在着相关性。而中老年干眼症状与眨眼频率及不完全眨眼比例无明显相关性。Lipiview~眼表面干涉仪是一种有效的干眼诊断辅助方法。

Objective To analyze the correlation between the dry eye symptom and signs in middle-aged and aged people by Lipiview^（？）ocular surface interferometry.Methods A total of 170 eyes from 85 middle-aged and aged people（55- 80 years old） were examined with Standard Patient Evaluaion of Eye Dryness（SPEED） questionnaire and Lipiview^（？）ocular surface interferometry,meanwhile obtaining the consent of the subjects.Then the correlation between the symptom and Lipid Layer Thinckness（LLT） and partial blink rate were analyzed.Results SPEED questionnaire score was 6.13±4.60.LLT was（74.88±21.16） nm.LLT variability was 4.47±3.40.The partial blink rate was 0.62±0.36.The Spearman correlation analysis indicated that the negative correlation was shown between the SPEED questionnaire score and LLT（r=-0.823,P=0.000）,SPEED questionnaire score and LLT variability（r =-0.268,P= 0.018）.The positive correlation were found between LLT and Std.Dev of LLT（r = 0.339,P =0.030）.However,the results of the SPEED score were uncorrelated with partial blink rate（P〉0.05）.Conclusion The results from this study demonstrate that correlation among symptom,LLT and LLT variability,but poor correlation between symptom and partial blink rate.