TGF-β在角膜损伤修复中的时间和空间分布

Temporal and spatial distribution of TGF-β in corneal wound healing

角膜损伤后的纤维化修复是角膜瘢痕形成的主要原因。转化生长因子-β(transforming growth factor-beta,TGF-β)在角膜的稳态平衡中起着至关重要的作用,是角膜损伤修复的重要参与者。同时,角膜上皮基底膜是角膜创伤修复过程中角膜上皮与基质相互作用的重要屏障。角膜损伤修复的不同阶段,各亚型TGF-β在角膜各种细胞及各个不同部位存在着分布差异,角膜上皮基底膜是否完整是影响该过程的重要因素。TGF-β不同亚型在时间和空间上的分布差异及变化与角膜的创伤修复过程中细胞的迁移、增殖、表型变化及细胞外基质沉着都紧密相关,是瘢痕愈合及无瘢痕愈合的细胞分子生物学基础。本文就TGF-β的生物学功能及其亚型在角膜损伤修复中的时间和空间分布情况作一综述。

Fibrosis is the major cause of corneal scarring.Transforming growth factor-beta（TGF-β） plays a key role in corneal homeostasis and repair.Corneal epithelial basement membrane is thought to be the important barrier of corneal epithelium-stroma interaction.In different stages of corneal wound healing,the isoforms of TGF-β have different temporal and spatial expression.The integrity of basement membrane is a critical factor of these procedures.The temporal and spatial distributions of TGF-β isoforms play the crucial roles in cell migration proliferation,phenotype changes and deposition of extracellular matrix in corneal wound healing.It is the mechanism of corneal scarring and scar-free healing.This article reviews recent articles to elucidate the biological functions of TGF-β and the temporal and spatial distribution of its isoforms in corneal wound healing.