金属催化腈水解反应制备伯酰胺衍生物的研究进展

Research progress of hydrdysis reaction of nitriles to form amide derivatives catalyzed by metal catalyst

鉴于金属催化腈水解制备伯酰胺衍生物的反应表现出高原子经济性、高选择性,对Mo系金属催化剂、Ru系金属催化剂、Rh系金属催化剂、Pd系金属催化剂、Au/Ag系金属催化剂等不同类型金属催化剂催化腈水解反应制备伯酰胺衍生物的研究进展进行了综述.提出,对腈水解反应制备伯酰胺衍生物的研究仍存在巨大的挑战,如非均相Ru系金属催化体系和选择性专一的伯酰胺催化剂体系的研发、均相和非均相催化体系反应机理的实验验证、将水作为唯一溶剂的研究等,都是未来的发展方向.

Considering the high atom economy and selectivity towards hydrolysis reaction derivatives of nitriles to form amides, progress in recent years for this transformation catalyzed by different metal catalysts was reviewed such as a variety of catalysts composed of transition-metal complexes such as Mo, Ru, Rh, Pd and Au/Ag. Specially, Ru-metal catalysts was exploited deeply and draw more attention of science researcher. However, hydrolysis reaction derivatives of nitriles to form amides catalyzed by metal catalysts remains a formi- dable challenge, including the development of heterogeneous Ru-metal catalysts and high selectivity catalysts, bringing insight into the mechanism of homogeneous and heterogeneous catalytic reaction, seeking for new sys- tem with pure water as solvent.