儿童过敏性紫癜患者肺炎支原体抗体的检测及其临床意义

Detection of Mycoplasma pneumoniae antibody in children with Henoch-Schonlein purpura and its clinical significance

目的:检测过敏性紫癜(HSP)患儿肺炎支原体抗体,阐明肺炎支原体感染与儿童HSP的关联性。方法:选择相同年龄段同期住院且符合诊断标准的HSP患儿323例、近期无感染病史的心律失常患儿52例、急性支气管炎患儿247例及支气管肺炎患儿122例,分别为HSP组、心律失常组、急性支气管炎组和支气管肺炎组,根据入组标准将HSP组患儿分为难治HSP组和一般HSP组。采用被动凝集法检测各组患儿血清中肺炎支原体抗体,并进行统计学分析。结果:HSP组有281例患儿检测肺炎支原体抗体,阳性153例(54.4%);心律失常组52例患儿均检测肺炎支原体抗体,阳性17例(32.7%);急性支气管炎组247例患儿均检测肺炎支原体抗体,阳性146例(59.1%);支气管肺炎组122例患儿均检测肺炎支原体抗体,阳性46例(37.7%)。与心律失常组和支气管肺炎组比较,HSP组患儿肺炎支原体抗体阳性率明显升高(P<0.05);与急性支气管炎组比较,HSP组患儿肺炎支原体抗体阳性率差异无统计学意义(P>0.05);难治性HSP组患儿较一般HSP组患儿肺炎支原体抗体阳性率明显升高(P<0.05)。结论:HSP患儿肺炎支原体抗体阳性率明显升高,且肺炎支原体可能使HSP患儿病情复杂。

Objective： To detect the Mycoplasma pneumoniae （MP）antibody in the children with Henoch-Schonlein purpura（HSP）,and to clarify the correlation between MP infection and HSP in the children.Methods： A total of 323 cases of hospitalized children with HSP in the same age group and period and in line with the diagnosis criteria. 52 cases of arrhythmia patients without a recent history of infection,247 cases of acute bronchitis and 122 cases of children with bronchopneumonia were selected as HSP, arrhythmia, acute bronchitis and bronchopneumonia groups.According to the standard set,the HSP patients were divided into refractory HSP group and general HSP group.Pssive agglutination method was to detect the MP antibody in serum of the children in various groups and statistical analysis was performed.Results： The MP antibodies in 281 children in HSP group were detected and they were positive in 153 cases （54.4%）; the MP antibodies in 52 cases in arrhythmia group were detected and they were positive in 17 cases （32.7%）;the MP antibodies in 247 cases in acute bronchitis group was detected and they were positive in 146 cases （59.1%）; the MP antibodies in 122 cases in bronchopneumonia group were detected and they were positive in 46 cases （37.7%）.Compared with arrhythmia and bronchiopneumonia groups,the positive rate of MP antibodies in HSP group was significantly increased（P〈0.05）;compared with acute bronchitis group,the positive rate of MP antibodies in HSP group had no significant difference（P〉0.05）.Compared with general HSP group,the positive rate of MP antibodies in refractory HSP group was significantly increased （P〈0.05）.Conclusion： The positive rate of MP antibodies in the children with HSP is increased;MP antibodies may make the HSP complicated in the HSP children.