电热针对膝骨关节炎患者氧化应激水平的影响

The Effect of Electrothermal Needle Acupuncture on Oxidative Stress Levels in Knee Osteoarthritis Patients

目的比较电热针和尼美舒利对膝骨关节炎的疗效及对疼痛的改善情况,并探讨电热针治疗膝骨关节炎的可能机制。方法将80例膝骨关节炎患者随机分为电热针组和西药组,每组40例。电热针组采用电热针疗法,西药组口服尼美舒利缓释片。治疗结束后评价疗效,手用疼痛视觉模拟评分法(VAS)评价两种方法对疼痛的改善作用。在治疗前及治疗后对所有受试者进行血清SOD、MDA的检测。结果电热针组治疗膝骨关节炎总体疗效优于西药组(P<0.05)。电热针组中膝骨关节炎患者疼痛VAS评分的改善与西药组无明显差异(P>0.05)。电热针组血清SOD在治疗后升高(P<0.05),MDA值在治疗后降低(P<0.05),西药组无明显变化(P>0.05)。结论电热针疗法能够很好地缓解膝骨关节炎的症状,其改善疼痛的效果与尼美舒利相当,电热针治疗膝骨关节炎的机制可能与其改善机体的氧化应激水平相关。

Objective To compare the efficacies of electrothermal needle acupuncture versus nimesulide in treating knee osteoarthritis and the relieving effects of them on the pain and explore the possible mechanism of electrothermal needle treatment for knee osteoarthritis. Method Eighty patients with knee osteoarthritis were randomly allocated to electrothermal needle and Western medicine groups, 40 cases each. The electrothermal needle group received electrothermal needle therapy and the Western medicine group took nimesulide sustainedrelease tablets. The therapeutic effects were compared after the completion of treatment. The relieving effects of the two treatments on the pain were evaluated using the Pain Visual Analogue Scale （VAS）. Serum SOD and MDA were measured in all the subjects before and after treatment. Result The marked efficacy rate and the total efficacy rate for knee osteoarthritis were higher in the electrothermal needle group than in the Western medicine group. There was no significant post-treatment difference in the VAS pain score between the electrothermal needle and Western medicine groups. After treatment, serum SOD increased and MDA decreased in the electrothermal needle group and they did not change significantly in the Western medicine group. Conclusion Electrothermal needle therapy can well relieve the symptoms of knee osteoarthritis. Its relieving effect on the pain is equal to that of nimesulide. The mechanism of electrothermal needle treatment for knee osteoarthritis may be related to its improving bodily oxidative stress levels.