结核活载体疫苗的研究进展

Advances in the study of tuberculosis live vector vaccines

目前,用于预防结核病的疫苗仍然是卡介苗(BCG),免疫效果不理想,原因颇为复杂;随着结核耐药菌株的出现,加上艾滋病感染与发病的增加,导致结核病发病人数逐年增多,所以研制新型结核病疫苗迫在眉睫。本文对近几年结核活载体疫苗的研究成果进行总结,为后续研究提供参考。

Currently, the BCG is used to prevent tuberculosis,but the immune effect is not ideal due to varied reasons. The existence of drug-resistant strains of tuberculosis and the increased prevalence and incidence of AIDS have leaded to the in- creased incidence of TB year by year. Therefore, the development of new tuberculosis vaccine is imminent. In this paper,the lat- est research results in recent years for tuberculosis live vector vaccines were summarized, which provide a theoretical reference for further research and development of new TB vaccines.