耳后注射甲泼尼龙琥珀酸钠与地塞米松治疗平坦型突发性聋的对比研究

Comparison of the effects of post-aural injection of methylprednisolone and dexamethasone in flat-type sudden hearing loss

目的探讨耳后注射甲泼尼龙琥珀酸钠(商品名:甲强龙)和地塞米松治疗平坦型突发性聋的疗效对比。方法选取我院就诊的平坦型突发性聋患者142例,随机分为甲强龙组与地塞米松组,两组均采用耳后乳突区骨膜局部注射激素的方法给药。比较两组患者疗效、听力改善情况以及不良反应。结果治疗后,甲强龙组和地塞米松组痊愈率分别为25.35%和16.90%,总有效率分别为88.73%和63.38%。两组患者痊愈率、无效率及总有效率相比,都具有统计学差异(P<0.05);治疗后,甲强龙组患者125~250 Hz平均值提高(26.5±4.3)d B;地塞米松组患者125~250 Hz平均值提高(18.5±6.2)d B;差异具有显著性(P<0.05)。结论耳后注射甲强龙治疗平坦型突发性聋的疗效优于地塞米松,本研究为临床提供了治疗依据。

OBJECTIVE To compare the effects of post-aural injection of methylprednisolone and dexamethasone in flat-type sudden hearing loss. METHODS 142 patients with flat-type sudden hearing lossin our hospital were selected and divided into methylprednisolone group and dexamethasone group randomly. All patients in these two groups received local injection of glucocorticoidsoncein mastoid periosteum. Patients in methylprednisolone group were injected methylprednisolone solution; Patients in dexamethasone group were injected dexamethasone solution. The efficacy, hearing improvement of two groups were compared. RESULTS After the treatment, the recovery rate of methylprednisolone and dexamethasone group were 25.35% and 16.90%, the total effective rate was 88.73% and 63.38%, respectively; Each clinical index between two groups had statistically significant difference（P0.05）; Moreover, the hearing improvement in methylprednisolone group was much better than dexamethasone group, withan averagedincrease of（26.5±4.3） d B in 125-250 Hz in methylprednisolone group while only（18.5±6.2） d B in 125-250 Hz in dexamethasone group, which demonstrated statistical significantly difference（P 〈0.05）. CONCLUSION The clinical efficacy of local injection with methylprednisolone was better than dexamethasone, and demostrated mild adverse reactions, which could be widely applied in clinical therapy.