低氧诱导因子与肝脏脂质代谢异常的相关性研究进展

Correlation Research Progress of Hypoxia Inducible Factors and Liver Lipid Metabolic Abnormalities

低氧诱导因子通过调控其下游靶基因表达对脂肪肝引起的脂质代谢紊乱产生适应性反应,同时介导阻塞性睡眠呼吸暂停相关肝脏脂质沉积,阻塞性睡眠呼吸暂停常与肥胖协同加重组织缺氧,导致严重的肝细胞脂肪变性及炎症。目前,国内外已有大量基础研究旨在探究低氧诱导因子在脂肪肝的发生发展过程中起着保护性作用还是有害的作用,但仍无定论。因而阐明低氧诱导因子调控肝脏脂质代谢的分子机制,将有利于利用低氧诱导因子这个有效靶点,在脂肪肝及其相关疾病中发挥治疗作用。

Hypoxia inducible factors（ HIFs） responds to the lipid metabolism disorder caused by fatty liver by regulating certain downstream gene expression.It also regulates liver lipid metabolism in the patients with obstructive sleep apnea. Obstructive sleep apnea and obesity synergistically accelerate tissue hypoxia,which further leads to severe hepatic steatosis and inflammation. At present,there are plenty of basic researches in worldwide,which aiming at exploring HIFs plays a protective role or harmful effect in the development of fatty liver.Therefore clarifying the molecular mechanisms of HIFs regulating liver lipid metabolism will allow effective targeting of HIFs as novel therapies in fatty liver and some other related diseases.