银氢柱除氯-液质联用法测定自来水中9种卤乙酸

Using OnGyardⅡAg/H Cartridges to Remove Chlorine in Tap Water for Nine Haloacetic Acids Analysis by UPLC-MS/MS

建立了自来水中9种痕量卤乙酸的超高效液相色谱串联质谱测定方法。自来水水样过银氢柱后用超高效液相色谱串联质谱测定,采用CSH氟苯基柱,流动相为含0.02%乙酸的水和乙腈,采用多反应监测(MRM)模式测定,电喷雾离子源(ESI),负离子扫描。结果表明,9种卤乙酸标准曲线线性相关系数(R^2)均≥0.991,加标浓度分别为5、10、100、200μg/L时,9种卤乙酸的回收率在61.0%~118.3%(n=4),测定结果的RSD(n=4)均小于16%,检出限范围为0.005~0.14μg/L。

A simple method to analyze nine haloacetic acids （HAAs） in tap water by UPLC-MS/ MS was developed. Tap water was passed through the OnGyard Ⅱ Ag/H cartridges before analysis. HAAS were separated by ACQUITY CSH fluoro phenyl column, using 0.02% acetic acid in water and acetonitrile as the mobile phase, and detected by negative electrospray ionization-tandem mass spectrometry, in multiple reaction monitoring （MRM） mode. The results showed that the correlation coefficients were ≥ 0. 991, the recoveries of nine target compounds in spiked tap water samples were 61.0% to 118.3% when the standard addition concentrations were 5 μg/L, 10 μg/L, 100 txg/L and 200 μg/L, the relative standard deviations （RSD, n = 4） were lower than 16%. The limits of detection were generally between 0. 005 to 0.14 μg/L.