原发性皮肤淋巴瘤研究进展

Research progress of primary cutaneous lymphoma

原发性皮肤淋巴瘤(PLC)是指原发于皮肤的具有明显异质性的淋巴增殖性疾病。病因及发病机制复杂,与遗传、感染、环境等多因素相关。其类型繁多,分类方法难以统一,而临床表现多缺乏特异性,诊断常需结合临床、组织病理、免疫表型和分子特征等。皮肤淋巴瘤生存期差异明显,治疗方法多样,预后情况不一。近年来,皮肤淋巴瘤临床研究不断深入,其发病机制、生物学特性、诊断和治疗方法都有了新的突破。

Primary cutaneous lymphoma （PCL） is a heterogeneous lymphoproliferative disorder that occurs primarily in the skin. The etiology and pathogenesis are complex, which are related to genetic, infectious, environmental and other factors. There are many kinds of subtypes, the classification methods are difficult to be unified, and the clinical manifestations are lack of specificity. The diagnosis should be combined with clinical, histopatbelogical, immunephenotypic and molecular characteristics. There are significant differences in the survival time of skin lymphoma, the treatment methods are various, and the prognosis is different. In recent years, much more has been known about the clinical research, pathogenesis, biological features, and have made some progress in diagnosis and treatment.