缺血性脑卒中患者血清Hcy和EPO水平的变化及其与颈动脉粥样硬化关系

Changes of Serum Hcy and EPO Levels in Patients with Ischemic Stroke and Their Relationship with Carotid Artery Atherosclerosis

目的分析缺血性脑卒中患者血清中同型半胱氨酸(Hcy)和促红细胞生成素(EPO)的水平变化及其与颈动脉粥样硬化之间的关系。方法选择某医院神经内科2013年1月1日~2016年7月31日之间收治的缺血性脑卒中患者作为研究对象,通过血清学检验Hcy,EPO水平,再通过多普勒探查颈动脉的方法,检查所有患者的颈动脉粥样硬化程度,并利用量化的方式记录下来,按照设定的诊断标准进行分级,利用分级结果与Hcy,EPO水平进行数据分析,判定两者之间的关系。结果 142例患者的多普勒探查结果显示,34例患者的颈动脉内中膜厚度正常,56例患者的颈动脉内中膜增厚,52例患者被判定到颈动脉斑块组,经过方差分析检验,Hcy,EPO两个项目在三个组别中差异均有统计学意义(F=59.64,78.29,P<0.05),经过q检验,任意两组之间的数据也同样出现统计学差异。对108例不同级别的颈动脉粥样硬化患者进行了分级,其中属于1级的47例,属于2级的34例,属于3级的27例,在不同级别患者血浆Hcy,EPO水平之间的对比,通过方差分析检验,差异均有统计学意义(F=78.39,48.61,P<0.05),经过q检验,任意两组之间的数据也同样出现统计学差异。结论人体血清中的Hcy和EPO与缺血性脑卒中有一定的相关性,并且同颈动脉粥样硬化的级别也有相关性。

Objective To analysis the levels of serum homocysteine （Hcy） and erythropoietin （EPO） levels in patients with ischemic stroke and their relationship with carotid atherosclerosis. Methods The patients with ischemic stroke admitted be tween January 1,2013 and July 31,2016 were selected as the subjects. Sera test of Hcy,EPO level, and then through the Doppler probe carotid artery method to check the degree of carotid atherosclerosis in all patients,and the use of quantitative records,according to set diagnostic criteria for classification, the use of grading results with the same type of Hcy,EPO lev- els of data analysis to determine the relationship between the two. Results Doppler exploration in 142 patients showed nor real carotid intima-media thickness in 34 patients, carotid intima-media thickening in 56 patients,and carotid plaques in 52 pa tients. After analysis of variance （F=59. 64,78. 29, P〈0.05）, and the difference between the two groups was statistically significant （P〈0.05）,and the difference between the two groups was statistically significant; The data between any two groups were also statistically significant differences. 108 patients with different levels of carotid atherosclerosis were graded into 47 of grade 1,34 of grade 2, and 27 of grade 3, with the same type in the plasma of different grades （F=78. 39,48. 61, P〈0.05）. After the qtest,there were no significant differences in the levels of Hcy and EPO. Data were also statistically dif- ferent between groups. Conclusion Serum homocysteine （Hcy） and erythropoietin （EPO） were associated with ischemic stroke and were associated with carotid atherosclerosis.