早发冠心病患者红细胞分布宽度与血清瘦素水平及其相关性分析

Analysis of the Relationship between Red Blood Cell Distribution Width and Serum Leptin Level in Patients with Premature Coronary Artery Disease

目的探讨早发冠心病患者红细胞分布宽度(RDWC)和血清瘦素(Leptin)水平及其相关性。方法搜集2013年1月~2016年4月因胸痛、胸闷于广东省佛山市高明区人民医院心血管内科经冠状动脉造影检查的住院患者320例,其中240例为男性≤55岁,女性≤65岁的冠心病患者(早发冠心病组);另80例为冠状动脉造影正常,运动平板阴性的男性≤55岁,女性≤65岁的患者,设为对照组。根据冠状动脉造影结果计算早发冠心病组Gensini评分,比较两组间红细胞分布宽度和血清瘦素水平差异,分析红细胞分布宽度和血清瘦素水平与冠状动脉病变程度的相关性。结果早发冠心病组患者红细胞分布宽度和血清瘦素水平分别为(13.87±0.31)%和(12.24±2.21)μg/L,显著高于对照组(14.31±0.22)%和(9.21±1.78)μg/L,差异有统计学意义(t=11.742,11.116,均P<0.001),并与冠状动脉Gensini评分呈正相关(r=0.413,0.124,P=0.000,0.041);红细胞分布宽度与血清瘦素水平呈正相关(r=0.107,P=0.008)。红细胞分布宽度对早发冠心病的预测价值进行研究对象工作特征曲线(ROC)分析显示:红细胞分布宽度的ROC曲线下面积(AUC)为0.725(95%CI:0.679~0.764),红细胞分布宽度界值为12.85%,敏感度为68.1%,特异度为65.4%。结论在早发冠心病患者中,红细胞分布宽度和血清瘦素水平均显著升高,且与冠状动脉病变程度呈正相关,可以作为早发冠心病的独立预测因子。

Objective To investigate the red blood cell distribution width （RDWC） and serum leptin （Leotin） levels in pa- tients with early onset coronary heart disease （CHD） and their correlation. Methods From January 2013 to April 2016,320 cases of hospitalized patients with chest pain, chest tightness in the cardiovascular department of the Gaoming District People ＇s Hospital of Foshan City,Guangddng Province,were examined by coronary artery. Of which 240 cases were male under 55 years old,female under 65 years old patients with coronary heart disease （coronary heart disease group） ,another 80 cases of normal coronary angiography and treadmill negative males under 55 years old, female under 65 years old patients,as the con- trol group. Gensini score in patients with premature coronary heart disease was calculated according to the coronary artery imaging results,Comparison between the two groups of red blood cell distribution width and serum leptin levels were differ ent,analysis of red blood cell distribution width and serum leptin levels and the correlation between the degree of coronary artery lesions. Results The red blood cell distribution width and the serum leptin level in patients with early onset coronary heart disease were （13.87± 0.31）% and （12.24 ± 2.21） μg/L, significantly higher than the control group （14.31 ±0. 22）% and （9.21±1.78） μg/L （t=11 742,11. 116,P〈0. 001）. And Gensini score was positively correlated with coro- nary artery （r= 0. 413,0. 124,P〈 0. 000,0. 041）. Correlation of red cell distribution width and serum leptin levels were posi- tively （r= 0. 107,P 〈 0. 008）. The research object curve the predictive value of red cell distribution width in patients with premature coronary heart disease （ROC） analysis showed that the area of ROC curve of red cell distribution width （AUC） under 0. 725 （95 %CI ： 0. 679- 0.764）, red cell distribution width value 12.85 %, the sensitivity was 68.1 %, specificity was 65.4%. Conclusion In patients with premature coronary heart disease,the red blood cell distribution width and serum leptin levels were significantly increased, and was positively correlated with the degree of coronary artery disease, can be used as an independent predictor of premature coronary heart disease.