摘要
目的肾原发性黏膜相关淋巴组织淋巴瘤(MALT淋巴瘤)罕见,该文探讨肾原发性MALT淋巴瘤的临床病理特征、诊断和鉴别诊断。方法对1例肾原发性MALT淋巴瘤进行临床检查、病理组织形态学观察及免疫组化染色,并复习相关文献。结果肾原发性MALT淋巴瘤临床与影像学检查结果缺乏特征性表现,组织学显示淋巴细胞弥漫性浸润,瘤细胞形态呈中心细胞样、单核细胞样,并可见浆细胞样细胞,显示淋巴上皮病变和滤泡植入现象,免疫组化染色结果显示:阳性染色结果:CD20+,PAX-5+,CD79α+,MUM-1+,阴性染色结果:CD3,CD5,CD45RO,bcl-2,CD10,bcl-6,CyclinD1;CD21显示破损的FDC网,kappa+,Lambda-,呈单克隆表型,Ki-67增殖指数约35%。病理诊断:肾原发性MALT淋巴瘤。结论肾原发性MALT淋巴瘤罕见,因缺乏特异性临床表现及影像学依据而极易误诊,明确诊断依赖病理学检查,免疫组化染色有助于鉴别诊断。
Objective Primary renal mucosa associated lymphoid tissue lymphoma （MALT lymphoma） is very rare,here dis cuss the clinical pathological characteristics and diagnosis,differential diagnosis of primary renal MALT lymphoma. Methods A case of primary renal MALT lymphoma was assayed for clinical and histopathological morphology,an well as immuno- histochemical staining,then reviewed the relevant literature. Results The clinical and imaging characteristics of renal lym- phoma lack of specific performance, the tissue section of the kidney biopsy showed diffuse infiltration of small lymphocytes. The small lymphocytes were centrocytes-like,monocytes-like,and plasma cell differentiation was recognized. Lymphoepithe- lial lesions were scattered. Follicular implanted phenomenon could been seen. Immunohistochemically result：the tumor cells were positive for CD20, PAX-5 ,CD79α and MUM-1, but negative for CD3 ,CD5, CD45RO, bcl-2, CD10, bcl-6 and CyclinD1. CD21 showed damage FDC network, positive for Kappa,negative for lambda, and it showed monoelonal phenotype, the Ki-67 index was about 35%. Final pathology diagnosis was primary renal MALT lymphoma. Conclusion Primary renal MALT lymphoma is very rare, the clinical manifestations and imaging characteristic of renal lymphoma are non-specific and misdiag- nosis frequently occurs in clinical practice, definite diagnosis depends on pathological examination,immunohistochemical stai- ning is helpful to differential diagnosis.
出处
《现代检验医学杂志》
CAS
2017年第1期121-123,127,共4页
Journal of Modern Laboratory Medicine
