黄芩汤辅助柳氮磺吡啶对溃疡性结肠炎患者血清TNF-α及白介素族水平影响研究

Effect of Huangqin Decoction Combined with Sulfasalazine on Serum TNF-α and Interleukin of Colitis Gravis Patients

目的:探讨黄芩汤辅助柳氮磺吡啶对溃疡性结肠炎患者血清TNF-α及白介素族水平的影响。方法:选取研究对象为74例溃疡性结肠炎患者,随机分成对照组和治疗组,每组37例。对照组给予柳氮磺吡啶治疗,治疗组在上述基础上再予黄芩汤治疗,两组均治疗1个月,测定治疗前后血清白介素族及TNF-α,免疫球蛋白水平和结肠黏膜菌群,观察疗效及安全性。结果:与治疗前比较,两组血清IL^(-1)β、IL-6及TNF-α水平明显降低(P<0.05),IL^(-1)0水平明显升高(P<0.05),血清Ig A及Ig G水平明显降低(P<0.05),结肠黏膜双歧杆菌及乳酸菌数量明显升高(P<0.05),大肠杆菌数量明显降低(P<0.05);与对照组比较,治疗组血清IL^(-1)β、IL-6及TNF-α水平较低(P<0.05),IL^(-1)0水平较高(P<0.05),血清Ig A及Ig G水平较低(P<0.05),结肠黏膜双歧杆菌及乳酸菌数量较高(P<0.05),大肠杆菌数量较低(P<0.05),治疗有效率较高(P<0.01),不良反应发生率较低(P<0.05)。结论:黄芩汤辅助柳氮磺吡啶能提高对溃疡性结肠炎的疗效,其可能机制为调整肠道菌群,调节免疫以及不同血清白介素的水平。

Objective ： To investigate the effect of Huangqin Decoction combined with Suffasalazine on serum TNF - α and interleukin of colitis gravis patients. Methods ： Seventy - four patients with ulcerative colitis were randomly divided into control group and treatment group,37 cases in each. The control group was treated with Sulfasalazine. The treatment group on the basis of the control group added Huangqi Decoction. Two groups were treated for 1 month. Results Compared with before treatment, serum IL - 1, IL - 6 and TNF - α levels decreased （ P 〈 0. 05 ） , IL - 10 levels increased （ P 〈 0. 05 ）,serum IgA and IgG levels decreased （P 〈 0. 05 ）, the number of colonic mucosal bifldobacteria and lactic acid bacteria increased （P 〈 0.05 ） , the number of Escherichia coli decreased （P 〈 0. 05 ）. Compared with the control group, serum IL- 1β, IL- 6 and TNF-α levels were lower （P 〈 0. 05 ）. Levels of IL- 10 were higher （P 〈 0. 05 ） and serum IgA and IgG levels were lower （ P 〈 0.05 ）. The colonic mucosal bifidobacteria and lactic acid bacteria amount were higher （P 〈0. 05）. The number of Escherichia coli was lower（P 〈0. 05） and the effective rate was higher （P 〈0. 01 ） and adverse reactions occur rate was lower （ P 〈 0. 05 ）. Conclusion ： Huangqin Decoction combined with Sulfasalazine in the treatment of colitis gravis was effective and it can adjust the intestinal flora,immune regulation and different levels of serum interleukin.