化学发光法检测降钙素原与血培养结果的相关性分析

Correlation Analysis of Serum Procalcitonin by Chemiluminescence Immunoassay and Blood Culture

目的研究降钙素原(PCT)与血培养结果的相关性。方法选取住院患者919例,采用化学发光法检测降钙素原检测结果≥0.05ng/m L的患者。同时进行血培养分析仪检测,对患者的降钙素原和血培养检测结果进行比对分析。结果血培养阳性患者150例,降钙素原为2.64±1.01ng/m L,血培养阴性患者769例,降钙素原为0.79±0.39ng/m L,两者比较P<0.05,差异有统计学意义。150例血培养阳性患者中,革兰氏阴性杆菌92例,降钙素原为5.79±2.81ng/m L,革兰氏阳性球菌有55例,降钙素原为1.59±0.61ng/m L,两者比较P<0.05,差异有统计学意义。结论降钙素原检测有助于细菌血流感染的诊断,值得临床推广应用。

Objective To investigate procalcitonin（ PCT） correlation with blood culture of bacteriology results.Methods Total of 919 cases of hospitalized patients were analyzed. The serum levels of procalcitonin were detected by chemiluminescence and blood culture of bacteriology analyzer were detectedfor patients with procalcitonin（ ≥0. 05 ng / m L）. Results 150 cases patients whose blood cultures were positive,the level of procalcitoninwas2. 64 ± 1. 01 ng / m L. In 769 patients whose blood cultures were negative,the level of procalcitonin was 0. 79 ± 0. 39 ng / m L. The difference between these two groups was statistically significant（ P 〈0. 05）. In the 150 cases patients with positive blood culture results,92 patients with gram-negative infection had procalcitonin level at 5. 79 ± 2. 81 ng / m L. Fifty five cases with gram-positive infection had procalcitonin level at 1. 59 ± 0. 61 ng / m L. The difference was statistically significant（ P 〈0. 05）. Conclusion Serum PCT testing has positive correlation with the results of bacterial blood culture. It can serve as a good marker in the early diagnosis of systemic bacterial infection,and is worthy of widespread clinical application.