冠心病患者血清小而密低密度脂蛋白胆固醇与同型半胱氨酸、D-二聚体含量分析

Analysis Between Serum Small Dense Low-density Lipoprotein Cholesterol and Homocysteine,D-dimer in Patients with Coronary Heart Disease

目的研究冠心病(CHD)患者血清小而密低密度脂蛋白胆固醇(sd LDL-C)与同型半胱氨酸(Hcy)、D-二聚体(D-dimer)含量,探讨其在CHD中的应用价值。方法 CHD患者125例,其中稳定性心绞痛(SAP组)42例,不稳定性心绞痛(UAP组)45例,急性心肌梗死(AMI组)38例。同期体检健康人群(对照组)45例。平行检测各组及CHD组中不同分支病变病人血清sd LDL-C、Hcy、D-dimer含量。结果对照组、SAP组、UAP组、AMI组血清sd LDL-C、Hcy、D-dimer含量依次增高,各组间差异具有统计学意义(P均<0.01)。CHD患者血清sd LDL-C、Hcy、D-dimer含量呈正相关(r=0.647,0.542,0.736,P均<0.01)。CHD患者冠状动脉3支病变与2支病变组血清sd LDL-C、Hcy、D-dimer含量均高于1支病变组(P均<0.01)。血清sd LDL-C、Hcy、D-dimer含量与CHD患者病变支数均呈正相关(r=0.547,0.631,0.482,P均<0.01)。结论对CHD患者行血清sd LDL-C、Hcy、D-dimer含量检测有助于早期诊断、临床分型及临床合理用药。

Objective To investigate the content changes of serum small,dense low-density lipoprotein cholesterol（ sd LDL-C）,homocysteine（ Hcy）,D-dimer（ D-dimer） in patients with coronary heart disease（ CHD） and discuss the application value in CHD. Methods We enrolled 125 patients with CHD and divided them into stable angina pectoris（ SAP） group 42 cases,unstable angina pectoris（ UAP） group 45 cases,acute myocardial infarction（ AM I） group 38 cases and healthy check-up 45 cases（ control group）. Parallel tests of serum sd LDL-C,Hcy,D-dimer with different groups and different branch lesions were conducted and compared. Results The serum sd LDL-C,Hcy,D-dimer in control group,SAP group,UAP group,AM I group successively increased,the differences were statistically significant（ P 〈0. 01）. The serum sd LDL-C,Hcy,D-dimer in CHD patients were positively correlated（ r = 0. 647,0. 542,0. 736,P 〈0. 01）. The serum sd LDL-C,Hcy,D-dimer in CHD patients with 3 lesions and 2 lesions were higher than the CHD patients with1 lesion（ all P 〈0. 01）. The serum sd LDL-C,Hcy,D-dimerwere positively correlated with different lesions in CHD patients（ r = 0. 547,0. 631,0. 482,P 〈0. 01）. Conclusion Detection of serum sd LDL-C,Hcy,D-dimer in CHD patients could help early diagnosis,clinical classification and clinical rational drug use.