琥珀酸美托洛尔治疗慢性收缩性左心衰竭的疗效

Therapeutic Effect of Metoprolol in the Treatment of Chronic Systolic Heart Failure

目的对比琥珀酸美托洛尔缓释片和酒石酸美托洛尔平片治疗慢性收缩性左心衰竭的效果。方法选取我院收治的40例慢性收缩性左心衰竭的患者作为研究对象,随机将40例患者分为观察组和对照组,每组各20例;对照组采用酒石酸美托洛尔平片治疗,观察组采用琥珀酸美托洛尔缓释片治疗。结果观察组在治疗过程中出现液体潴留1例,不良反应发生率为5.00%;对照组在治疗过程中出现体液潴留2例、低血压2例,不良反应发生率为20.00%;不良反应发生率比较,观察组低于对照组,差异具有统计学意义(χ2=10.285 7,P=0.001 3)。结论在对慢性收缩性左心衰竭患者的治疗时,琥珀酸美托洛尔缓释片可明显降低不良反应。

Objective To compare Metoprolol Succinate Sustained-release Tablets and metoprolol flat tablets in the treatment of chronic systolic left heart failure effect. Methods In our hospital, 40 cases of chronic systolic heart failure patients as the research object and were randomly divided into observation group and control group, 20 cases in each group. Control group received metoprolol tartrate tablets in the treatment of flat, observation group for treatment of metoprolol succinate sustained-release Tablets. Results The observation group and 1 cases of fluid retention during treatment, the incidence of adverse reaction was 5.00%; the control group in the treatment of 2 cases appeared in the process of fluid retention in 2 cases, low blood pressure, the incidence of adverse reaction was 20.00%; the incidence of adverse reactions, the observation group was significantly lower than the control group, significant difference significant（χ^2=10.285 7, P=0.001 3）. Conclusion In the treatment of chronic systolic left heart failure patients, metoprolol succinate sustained-release tablets cansignificantly reduce the adverse reaction.