全脑放疗联合替莫唑胺化疗与单纯全脑放疗对脑转移性肿瘤疗效

Efficacy of Whole Brain Radiotherapy Combined With Chemotherapy and Radiotherapy Alone in the Treatment of Brain Metastases

目的对比观察单纯全脑放疗、全脑放疗与替莫唑胺化疗联合治疗在脑转移性肿瘤患中的治疗效果。方法采用随机分组法将100例脑转移性肿瘤患者分为联合组和对照组,各50例。对照组单独采用全脑放疗,联合组采用全脑放疗与替莫唑胺化疗联合治疗。治疗5周,观察两组患者治疗效果、半年内复发率、不良反应发生情况。结果联合组病情总缓解率优于对照组;联合组复发率低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论全脑放疗与替莫唑胺化疗联合治疗对脑转移性肿瘤的疗效可以优化治疗效果,不增加不良反应。

Objective To observe the therapeutic effect of combined therapy of whole brain radiotherapy, whole brain radiotherapy and chemotherapy combined with radiotherapy for patients with brain metastases. Methods 100 cases of brain metastatic tumors were randomly divided into the combination group and the control group, 50 cases in each group. Patients in the control group were treated with whole brain radiotherapy alone, and the combination group was treated with whole brain radiotherapy combined with chemotherapy. 5 weeks of treatment, observation of two groups of patients with treatment effect, the recurrence rate, adverse reactions occurred within six months. Results The overall remission rate of the combined group was significantly better than that of the control group; the recurrence rate of the combined group was significantly lower than that of the control group, and the difference was statistically significant（P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P〉0.05）. Conclusion The whole brain radiotherapy combined with chemotherapy for the treatment of brain metastatic tumors can optimize the treatment effect, don＇t increase the adverse reaction.