H型高血压病痰瘀互结证相关因素的临床分析

The clinical analysis of correlative factors of phlegm and blood stasis syndrome in hypertension

[目的]探讨H型高血压病痰瘀互结证与临床常见危险因素的相关性,探讨不同性别间多种相关危险因素间可能存在的差异。[方法]选取高血压病合并高同型半胱氨酸血症(HHcy)患者215例,按中医证型分为两个亚组,痰瘀互结证组117例,非痰瘀互结证组98例(对照组)。分别测定同型半胱氨酸(Hcy)、甘油三酯(TG)、总胆固醇(TC)、载脂蛋白a(Lpa)、空腹血糖(FPG)、血尿酸(UA)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、体重指数(BMI)、腹围(AC),对各项检测结果进行统计学分析。[结果]1)两组间在Hcy、TG、TC、Lpa、FPG、UA检测指标水平方面比较,差异无统计学意义(P>0.05),LDL、HDL、BMI、AC检测指标水平方面比较,差异有统计学意义(P<0.05)。2)两组男性患者对比,Hcy、TG、TC、Lpa、FPG、UA、HDL检测指标水平方面比较,差异无统计学意义(P>0.05),LDL、BMI、AC检测指标水平对比,差异有统计学意义(P<0.05),其中两组男性患者BMI指数比较,差异明显有统计学意义(P<0.01)。3)两组女性患者对比,Hcy、TG、TC、Lpa、UA、HDL、LDL、BMI、AC检测指标水平方面比较,差异无统计学意义(P>0.05),两组女性患者FPG水平比较,差异有统计学意义(P<0.05)。[结论]1)LDL、HDL水平、肥胖(BMI≥28)可能是H型高血压病痰瘀互结证的相关危险因素。2)男性H型高血压病痰瘀互结证患者可能更易出现超重(25<BMI<28)或肥胖(BMI≥28)和LDL水平升高;而女性患者可能逐渐表现出空腹血糖(FPG)的改变。

[Objective] To investigate the correlation common risk factors of H-Hypertension phlegm and blood syndrome, and to explore the feasible differences between male and female. [Methods] The 215 H-Hypertension patients were divided into two subgroups according to Chinese medicine syndromes,group of phlegm and blood syndrome（n=117）, group of non-phlegm and blood syndrome（n=98）, calculating and comparing the statistics of Hcy, TG, TC, Lpa, FPG, UA, LDL, HDL, BMI index, AC among all groups, test results were statistically analyzed. [Results] 1 ）Two groups compared with TG, TC, Lpa, FPG, UA,the difference was not statistically significant （P〉 0.05）,comparison of LDL, HDL, BMI, AC, the difference was statistics significance （P〈0.05）. 2）The groups of male patients compared With Hcy, TG, TC, Lpa, FPG, UA, HDL, the difference was not statistically significant （P〉0.05）, comparison of LDL, BMI, AC, the difference was statistically significant （P〈0.05）, in which two groups of male patients BMI index,significant differences were statistically significant （P〈0.01）. 3）The groups of male patients compared with Hcy, TG, TC, Lpa, UA, HDL, LDL, BMI, AC, the difference was not statistically significant （P〉0.05）, comparison of FPG,the difference was statistically significant （P〈0.05）. [Conclusion] 1）LDL, HDL, obesity（BMI≥ 28） may be the related risk factors of H-Hypertension in phlegm syndrome. 2）Overweight （25〈BMI〈28）or obesity （BMI ≥ 28）,elevated LDL may be the related risk factors of male in H-Hypertension phlegm syndrome,and elevated FPG levels may be the related risk factor of female in H-Hypertension phlegm syndrome.