维格列汀联合二甲双胍治疗2型糖尿病的临床效果及其安全性

Clinical effect of vildagliptin combined with metformin in the treatment of type 2 diabetes mellitus and the safety

目的探讨维格列汀联合二甲双胍治疗2型糖尿病的临床疗效及其安全性。方法选取辽阳市第二人民医院2015年2月—2016年3月收治的2型糖尿病患者100例,采取随机双盲法分为对照组和试验组,各50例。对照组患者给予二甲双胍加量治疗,试验组患者给予采取维格列汀联合二甲双胍治疗。比较两组患者的糖化血红蛋白、空腹血糖及餐后2 h血糖,并观察比较药物不良反应发生情况。结果试验组患者糖化血红蛋白高于对照组,空腹血糖及餐后2 h血糖低于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论二甲双胍联合维格列汀治疗2型糖尿病效果明显,可有效控制血糖,不良反应少,安全性高。

Objective To explore the clinical effect of vildagliptin combined with metformin in the treatment of type 2diabetes mellitus and the safety. Methods A total of 100 cases of type 2 diabetes mellitus patients were selected from February2015 to March 2016 in the Second People＇s Hospital of Liaoyang City,which were divided into control group and experimental group according to random double blind method,50 cases in each group. Control group was given metformin,experimental group was given vildagliptin combined with metformin. The glycosylated hemoglobin,GLU,postprandial blood glucose 2 h and the incidence of the incidence of adverse reactions were compared between two groups. Results Experimental group of glycosylated hemoglobin was higher than control group,GLU and postprandial blood glucose 2 h were lower than control group（ P〈0. 05）.No statistical significant difference of adverse reactions was found between the two group（ P〈0. 05）. Conclusion Vildagliptin combined with metformin in the treatment of type 2 diabetes mellitus have an obviously clinical effect and less adverse reactions,and with good safety.