避孕药物联合胰岛素增敏剂治疗多囊卵巢综合征的临床疗效观察

Clinical effect observation of contraceptives combined with polycystic ovary syndrome in the treatment of polycystic ovary syndrome

目的探讨避孕药物联合胰岛素增敏剂治疗多囊卵巢综合征的临床疗效。方法选取厦门市第五医院2014年1月—2015年1月收治的多囊卵巢综合征患者120例,按照随机数字表法分为对照组和观察组,各60例。对照组患者给予达英-35治疗,观察组患者在对照组基础上联合二甲双胍治疗,均持续治疗12周。观察比较两组患者的性激素指标[睾酮(T)、黄体生成素(LH)及卵泡刺激素(FSH)]及排卵恢复时间、正常受孕时间。结果治疗前,两组患者T、LH及FSH比较,差异无统计学意义(P<0.05);治疗后,观察组患者T、LH及FSH低于对照组(P<0.05)。观察组患者排卵恢复时间、正常受孕时间短于对照组(P<0.05)。结论避孕药物联合胰岛素增敏剂治疗多囊卵巢综合征的临床效果明显,可有效改善患者的T、LH、FSH水平,缩短患者症状改善时间。

Objective To explore the clinical effect of contraceptives combined with polycystic ovary syndrome in the treatment of polycystic ovary syndrome. Methods A total of 120 cases of polycystic ovary syndrome patients were selected from January 2014 to January 2015 in the Fifth Hospital of Xiamen,which were randomly divided into control group（ n = 60） and observation group（ n = 60）. The control group was treated with diane-35,observation group was treated with insulin sensitivity agent based on control group. The sex hormone index（ T,LH,FSH） and ovulation recovery time,pregnancy time were compared between the two groups. Results Before treatment,no significant differences of T,LH,FSH was found between the two groups（ P〈0. 05）; after treatment,the observation group of T,LH,FSH were lower than control group（ P〈0. 05）. The observation group of ovulation recovery time and pregnancy time were shorten than control group（ P〈0. 05）. Conclusion Contraceptives combined with polycystic ovary syndrome have an obviously clinical effect in the treatment of polycystic ovary syndrome,it can effectively improve the T,LH,FSH levels,and shorten the symtome improvement time.