奥扎格雷联合依达拉奉治疗老年急性进展性脑梗死的临床观察

Clinical observation of ozagrel combined with edaravone in the treatment of senile acute progressive cerebral infarction

目的观察奥扎格雷联合依达拉奉治疗老年急性进展性脑梗死的疗效及毒副反应。方法将80例急性进展性脑梗死的老年患者随机分为观察组和对照组各40例。2组患者均给予常规治疗,观察组同时给予奥扎格雷联合依达拉奉,对照组给予奥扎格雷联合胞二磷胆碱。根据卒中临床神经功能缺损评定标准(NIHSS)和日常生活能力(ADL)评分分别在治疗前后对2组患者进行评估。结果观察组有效率为87.5%均明显高于对照组的72.5%,差异有统计学意义(P<0.05),治疗前2组NIHSS评分、ADL评分差异均无统计学意义(P>0.05),治疗后2组患者NIHSS评分均降低,ADL评分均升高,且观察组变化幅度大于对照组,差异均有统计学意义(P<0.05)。2组均未见不良反应,所有患者治疗后血常规、肝肾功能、出凝血时间、心电图检查均无异常改变。结论奥扎格雷联合依达拉奉能明显改善老年急性进展性脑梗死患者神经功能缺损症状,且比较安全,值得进一步研究。

Objective To observe the effect of ozagrel combined with edaravone in the treatment of senile acute pro- gressive cerebral infarction. Methods 80 old patients with acute progressive cerebral infarction were randomly divided into ob- servation group and control group, each of 40 cases. The patients in two groups were treated with routine therapy. The patients in observation group were given the combination of ozagrel and edaravone, while control group was given the combination of oza- grel and citicoline. The NIHSS and ADL scores were monitored before and after the treatment of two groups. Results The ef- fective rate of observation group was 87.5% significantly higher than 72.5% of control group, the difference was statistically significant（ P 〈 0.05 ）. There was no statistically significant difference in NIHSS score and ADL score between two groups be- fore treatment （ P 〉 0.05 ）. After treatment, the NIHSS scores of both groups were decreased, ADL scores were increased, and observation group changes range were greater than control group, the differences were statistically significant （ P 〈 0.05 ）. No adverse effects were observed in two groups, and after treatment, the blood routine, liver and kidney function, a clotting time, ECG of all patients were no abnormal changes. Conclusion Oozagrel combined with edaravone in the treatment of senile acute progressive cerebral infarction could significantly reduce neurological deficits with no significant adverse effect, but more re- search is required.