米索前列醇不同给药途径用于早期妊娠药物流产的临床比较

Clinical comparison of different ways of administration of misoprostol for early pregnancy drug abortion

目的比较米索前列醇不同给药途径用于早期妊娠药物流产的临床效果。方法将自愿终止妊娠女性180例根据米索前列醇给药方式不同随机分成A、B、C 3组各60例,A组口服给药;B组阴道给药;C组舌下给药。比较3组患者的流产成功率,阴道出血量、孕囊排出时间和不良反应发生率。结果 B组、C组流产成功率均高于A组(P<0.05),但B组、C组间流产成功率比较差异无统计学意义(P>0.05)。B组、C组的阴道出血量明显少于A组,孕囊排出时间明显短于A组(P<0.05),但B组、C组间阴道出血量和孕囊排出时间比较差异无统计学意义(P>0.05)。B组不良反应发生率(10.0%)明显低于A组(33.3%)和C组(23.3%),差异有统计学意义(P<0.05)。结论阴道给药及舌下给药方式流产成功率高于口服给药,值得临床大力推广。

Objective To compare the clinical effect of different routes of administration of misoprostol for early preg- nancy drug abortion. Methods 180 cases of voluntary termination of pregnancy women,according to the different ways of mi- soprostol administration,were randomly divided into A, B, C group, each of 60 cases. Group A received oral administration; Group B received vaginal administration; Group C received sublingual administration. The success rate of abortion, vaginal bleeding volume,gestational sac discharge time and adverse reaction rate were compared among three groups. Results The successful rate of abortion in group B and group C was higher than that in group A （ P 〈 0.05 ）, but there was no significant difference in the success rate of abortion between group B and group C （ P 〉 0.05 ）. The vaginal bleeding in group B and group C was significantly less than group A,the gestational sac discharge time in group B and group C was significantly shorter than group A （ P 〈 0.05 ）. But there was no significant difference between group B and group C （ P 〉 0.05 ） in vaginal bleeding vol- ume and gestation time. The incidence of adverse reactions in group B（ 10.0% ） was significantly lower than that in group A （33.3%） and group C （23.3%）, the difference was statistically significant（ P 〈 0.05 ）. Conclusion The success rate of va- ginal administration and sublingual administration of abortion is higher than that of oral administration, which is worth populari- zing clinically.