小剂量阿司匹林联合泼尼松治疗RSA的疗效观察

Clinical effect observation of low-dose aspirin combined with prednisone in recurrent miscarriage

目的观察小剂量阿司匹林联合泼尼松治疗复发性流产(RSA)的临床效果。方法将RSA患者70例随机分为观察组和对照组各35例,观察组采用小剂量阿司匹林联合泼尼松,对照组采用常规保胎治疗,观察2组患者治疗成功率和治疗前后绒毛膜促性腺激素(HCG)、孕酮(P)、雌二醇(E2)水平。结果观察组治疗成功率为94.29%明显高于对照组的77.14%,差异有统计学意义(P<0.05);2组患者治疗前HCG、P、E2水平比较差异均无统计学意义(P>0.05),治疗后2组HCG、P、E2水平均升高,且观察组高于对照组,差异均有统计学意义(P<0.05)。结论小剂量阿司匹林联合泼尼松治疗RSA效果显著,治疗成功率高,能显著改善患者激素水平,值得临床推广使用。

Objective To observe the clinical effect of low-dose aspirin combined with prednisone in recurrent mis- carriage. Methods 70 eases patients with recurrent miscarriage were randomly divided into research group and conventional group,each of 35 cases. The observation group was treated with low-dose aspirin combined with prednisone. The control group was treated with routine miscarriage therapy. After treatment, compared the treatment success rate and the level of HCG, proges- terone and estradiol （ E2 ） before and after treatment of 2 groups. Results The treatment success rate of research group was 94.29%, which was significantly higher than that of the control group （77.14%）, the difference was statistically significant （ P 〈 O. 05 ）. There was no significant difference in HCG, P, E2 levels between the two groups before treatment （ P 〉 0.05 ）. M- ter treatment, the levels of these hormones increased, and the observation group was higher than the control group, the difference was statistical significance （ P 〈 0.05）. Conclusion Low-dose aspirin combined with prednisone in the treatment of recurrent miscarriage has an good effect, the success rate is high, can significantly improve the patient＇s hormone levels, worthy of clinical application.