抗痛风药非布司他的合成方法研究进展

Analysis of the Synthesis Method about Anti-gout Drug Febuxostat

文章总结了抗痛风新药——非布司他的合成方法,通过不同合成路线、操作方式的分析和比较,发现目前研究的热点在于对工艺中剧毒、强腐蚀性的试剂进行替换,以及对反应设备、反应条件的改进。文章希望通过对该药物的合成方法进行综述,为我国医药企业改进这一药物的合成路线,寻找更加绿色、环保、可工业化生产的方法提供研究思路和参考。

The article summarizes the synthesis method about the anti-gout drug febuxostat. Present study is focus on how to replace the highly toxic reagent and strong corrosive reagent in the reaction, and how to improve the reaction equipment and the reaction conditions. The article summarizes the synthesis methods of febuxostat in order to provide more reference on improving synthesis route, looking lbr green, environmental friendly and industrial manufacture methods.